ArticleInternational journal of nanomedicine2015
Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles.
Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Unlocking the Therapeutic Efficacies of Silver Nanoparticles Derived Using the Plant-Based Aqueous Extract: A Comprehensive Review.Applied biochemistry and biotechnology · 2026Review
- Exploring the anticancer potential of traditional herbs from Tamil Nadu: a narrative review of ethnomedicinal insights and scientific evidence.Frontiers in immunology · 2025Review
- Relevance of Indian Traditional Herbal Brews for Gut Microbiota Balance.Indian journal of microbiology · 2024Review
- Biosynthesized Silver Nanoparticles UsingACS omega · 2023Article
- A novel approach for the biosynthesis of silver nanoparticles using the defensive gland extracts of the beetle, Luprops tristis Fabricius.Scientific reports · 2023Article
- Synthesis and Characterization of Mithun (Biomedicines · 2023Article
- Anti-Tumor Potential ofAntioxidants (Basel, Switzerland) · 2023Article
- Review
- Phytofabricated Nanoparticle Formulation for Cancer Treatment: A Comprehensive Review.Current drug metabolism · 2022Review
- Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?Nanomaterials (Basel, Switzerland) · 2021Review
- Article
- A potential role of green engineered TiOEnvironmental science and pollution research international · 2021Article
- Eco friendly silver nanoparticles synthesis by Brassica oleracea and its antibacterial, anticancer and antioxidant properties.Scientific reports · 2020Article
- Unveiling the cytotoxicity of phytosynthesised silver nanoparticles usingIET nanobiotechnology · 2020Article
- Green Chemistry Synthesis of Silver Nanoparticles and Their Potential Anticancer Effects.Cancers · 2020Review
- De novo transcriptome of Gymnema sylvestre identified putative lncRNA and genes regulating terpenoid biosynthesis pathway.Scientific reports · 2019Article
- Alpinia calcarata: potential source for the fabrication of bioactive silver nanoparticles.Nano convergence · 2018Article
- Biosynthesis of silver nanoparticles formation fromJournal, genetic engineering & biotechnology · 2018Article
- Article
- Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract ofBioinorganic chemistry and applications · 2018Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundGymnema sylvestre is an ethno-pharmacologically important medicinal plant used in many polyherbal formulations for its potential health benefits. Silver nanoparticles (SNPs) were biofunctionalized using aqueous leaf extracts of G. sylvestre. The anticancer properties of the bioactive compounds and the biofunctionalized SNPs were compared using the HT29 human adenoma colon cancer cell line.
methodsThe preliminary phytochemical screening for bioactive compounds from aqueous extracts revealed the presence of alkaloids, triterpenes, flavonoids, steroids, and saponins. Biofunctionalized SNPs were synthesized using silver nitrate and characterized by ultraviolet-visible spectroscopy, scanning electron microscopy, energy-dispersive X-ray analysis, Fourier transform infrared spectroscopy, and X-ray diffraction for size and shape. The characterized biofunctionalized G. sylvestre were tested for its in vitro anticancer activity against HT29 human colon adenocarcinoma cells.
resultsThe biofunctionlized G. sylvestre SNPs showed the surface plasmon resonance band at 430 nm. The scanning electron microscopy images showed the presence of spherical nanoparticles of various sizes, which were further determined using the Scherrer equation. In vitro cytotoxic activity of the biofunctionalized green-synthesized SNPs (GSNPs) indicated that the sensitivity of HT29 human colon adenocarcinoma cells for cytotoxic drugs is higher than that of Vero cell line for the same cytotoxic agents and also higher than the bioactive compound of the aqueous extract.
conclusionOur results show that the anticancer properties of the bioactive compounds of G. sylvestre can be enhanced through biofunctionalizing the SNPs using the bioactive compounds present in the plant extract without compromising their medicinal properties.
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