ArticleIndian journal of dentistry2014
Mutations in the MSX1 gene in Turkish children with non-syndromic tooth agenesis and other dental anomalies.
Article in Indian journal of dentistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 17 citations in OpenAlex.
- NovelChildren (Basel, Switzerland) · 2024Article
- Is there an association between molar incisor hypomineralization and developmental dental anomalies? A case-control study.BMC oral health · 2023Article
- Novel MSX1 variants identified in families with nonsyndromic oligodontia.International journal of oral science · 2021Article
- Research algorithm for the detection of genetic patterns and phenotypic variety of non-syndromic dental agenesis.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieObservational
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
aimTo search for mutations on the MSX1 gene and to present a genetic basis for non-syndromic tooth agenesis in conjunction with dental anomalies in a Turkish population. MATERIALS AND
methodsThe patients included in this study were otherwise healthy, with ages ranging from seven to eighteen years. Eighty-two of them had one to six teeth missing (Group I) and 26 had more than six teeth missing (Group II), except for the third molars,. The missing teeth and dental anomalies were examined clinically and radiographically. The MSX1 gene was sequenced from the blood samples of patients who consented to the study.
resultsMutations or polymorphisms on the MSX1 gene were identified in six patients. Taurodontism was seen in patients from both groups I and II. The nucleotide changes were identified by mutation screening.
conclusionsPerforming family studies, screening other candidate genes, and investigation of interactions between genes will provide a basis for better analysis of tooth agenesis models and their association with other dental anomalies.
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