Changes in blood pressure following escalating doses of phenylpropanolamine and a suggested protocol for monitoring.

Gilad Segev, Jodi L Westropp, Chen Kulik, Eran Lavy

Open access · greenAbstract read

In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

ACVIM consensus statement on diagnosis and management of urinary incontinence in dogs.Journal of veterinary internal medicine
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gilad SegevSchool of Veterinary Medicine, the Hebrew University of Jerusalem, Israel, P.O. Box 12, Rehovot, 76100, Israel (Segev, Kulik, Lavy); Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA (Westropp).

Jodi L WestroppSchool of Veterinary Medicine, the Hebrew University of Jerusalem, Israel, P.O. Box 12, Rehovot, 76100, Israel (Segev, Kulik, Lavy); Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA (Westropp).

Chen KulikSchool of Veterinary Medicine, the Hebrew University of Jerusalem, Israel, P.O. Box 12, Rehovot, 76100, Israel (Segev, Kulik, Lavy); Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA (Westropp).

Eran LavySchool of Veterinary Medicine, the Hebrew University of Jerusalem, Israel, P.O. Box 12, Rehovot, 76100, Israel (Segev, Kulik, Lavy); Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA (Westropp).

Hebrew University of Jerusalem · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This prospective, cross-over, blinded study evaluated the effect of various doses of phenylpropanolamine (PPA) on blood pressure in dogs. Dogs were randomized to receive a placebo or 1 of 3 dosages of immediate release PPA, q12h for 7 days [1 mg/kg body weight (BW), 2 mg/kg BW, or 4 mg/kg BW] in a cross-over design. Blood pressure was recorded every 2 h, for 12 h, on days 1 and 7. There were significant increases in systolic, diastolic, and mean blood pressure following administration of PPA at 2 mg/kg BW and 4 mg/kg BW. A significant decrease in heart rate was also noted at all PPA dosages, but not in the placebo. Administration of PPA was associated with a dose response increase in blood pressure. Dosages of up to 2 mg/kg BW should be considered safe in healthy dogs.

Indexed as

Adrenergic alpha-AgonistsAnimalsBlood PressureBlood Pressure Monitoring, AmbulatoryCross-Over StudiesDogsDose-Response Relationship, DrugFemaleHeart RateMalePhenylpropanolamineAdrenergic alpha-AgonistsPhenylpropanolamine

Identifiers

PMID25565712

PMCPMC4266053

OpenAlexW2401480450

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.