SynthesisCanadian journal of psychiatry. Revue canadienne de psychiatrie2014
The role of untreated psychosis in neurodegeneration: a review of hypothesized mechanisms of neurotoxicity in first-episode psychosis.
Synthesis in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Early interventions in mental health services: a rapid review of systematic review.Frontiers in public health · 2026Pooled it
- Association of Pre-onset Subthreshold Psychotic Symptoms With Longitudinal Outcomes During Treatment of a First Episode of Psychosis.JAMA psychiatry · 2019Trial
- Toward precision medicine: can neuroimaging prospectively predict early treatment outcomes in schizophrenia spectrum disorders? A systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Review
- Evaluation of the Electroconvulsive Therapy's Impact on Retinal Structures in First-Episode Psychosis Patients Using Optical Coherence Tomography.Schizophrenia bulletin · 2026Article
- Psychiatric antecedents in young patients with first episode psychosis: what relevance for clinical outcomes?European archives of psychiatry and clinical neuroscience · 2025Article
- First Episode Psychosis in Patients Aged 18 to 30 Admitted Involuntarily: Characteristics and Risk Factors for Functional Non-Remission.Brain sciences · 2025Article
- Cerebral Computed Tomographic Findings in Schizophrenia: Relationship to Second-Generation Antipsychotics and Hyperprolactinemia.Healthcare (Basel, Switzerland) · 2024Article
- Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?European child & adolescent psychiatry · 2024Article
- The Association of Antipsychotic Postponement With 5-Year Outcomes of Adolescent First-Episode Psychosis.Schizophrenia bulletin open · 2023Article
- Aripiprazole LAI two-injection start in a 16 year-old adolescent with schizophrenia.Neuropsychopharmacology reports · 2022Article
- White matter integrity, duration of untreated psychosis, and antipsychotic treatment response in medication-naïve first-episode psychosis patients.Molecular psychiatry · 2021Article
- Adolescent Neurodevelopment and Vulnerability to Psychosis.Biological psychiatry · 2021Review
- A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone?The international journal of neuropsychopharmacology · 2020Article
- Duration of Untreated Psychosis Correlates With Brain Connectivity and Morphology in Medication-Naïve Patients With First-Episode Psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Early intervention services for non-psychotic mental health disorders: a scoping review protocol.BMJ open · 2019Article
- Psychiatric Symptoms in Amyotrophic Lateral Sclerosis: Beyond a Motor Neuron Disorder.Frontiers in neuroscience · 2019Review
- DNA Methylation Changes in Intron 1 ofFrontiers in neuroscience · 2017Article
- Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study.Neuropsychiatric disease and treatment · 2016Article
- Kraepelin revisited: schizophrenia from degeneration to failed regeneration.Molecular psychiatry · 2015Review
- How does untreated psychosis lead to neurological damage?Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
For over 20 years, studies have tried to measure the association between the duration of untreated psychosis (DUP) and changes in brain morphology. A hypothesis that untreated psychosis is neurotoxic has been postulated, but the mechanisms of that toxicity have not been described. We re-analyzed papers collected for a systematic review to extract data on the hypotheses that have been generated on the potential mechanisms by which DUP could impact brain morphology in first-episode psychosis. Dopaminergic hyperactivity, prolonged hypothalamic-pituitary-adrenal activation, and persistent activity of catecholamines have been hypothesized as mechanisms to explain these associations. However, the question remains as to whether the observed structural changes are permanent or may be reversed via antipsychotic treatment.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.