ReviewThe Journal of physiology2015
Intrapulmonary arteriovenous anastomoses in humans--response to exercise and the environment.
Review in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Decreased arterial PO2, not O2 content, increases blood flow through intrapulmonary arteriovenous anastomoses at rest.The Journal of physiology · 2016Trial
- Post-mortem CT detection of fatal air embolism after aerosolized fibrin glue for bladder bleeding.Journal of forensic sciences · 2026Article
- Case Report: Concurrent ventricular septal defect, pulmonic stenosis, and intrapulmonary arteriovenous anastomoses in a Korean raccoon dog (Frontiers in veterinary science · 2026Article
- A hypothesis-driven pulmonary-cerebral mechanistic framework of neurological decompression illness in repetitive breath-hold diving.Frontiers in physiology · 2026Review
- Hereditary haemorrhagic telangiectasia.Nature reviews. Disease primers · 2025Review
- Contribution of intrapulmonary shunt to the pathogenesis of profound hypoxaemia in viral infection: a mechanistic discussion with an illustrative case.Journal of the Intensive Care Society · 2024Article
- Evaluation of intrapulmonary arteriovenous anastomoses before and after oxygen supplementation, using transthoracic agitated saline contrast echocardiography in rescued Korean raccoon dogs.Frontiers in veterinary science · 2024Article
- Pulmonary Arteriovenous Malformation: Not all Hypoxemia During Covid-19 is the Same.European journal of case reports in internal medicine · 2024Article
- Hyperoxia-induced stepwise reduction in blood flow through intrapulmonary, but not intracardiac, shunt during exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Impact of COVID-19 pneumonia on pulmonary vascular volume.Frontiers in medicine · 2023Article
- Neglected intrapulmonary arteriovenous anastomoses: A comparative study of pulmonary right-to-left shunts in patients with patent foramen ovale.Frontiers in cardiovascular medicine · 2023Article
- Choroidal arteriovenous anastomoses: a hypothesis for the pathogenesis of central serous chorioretinopathy and other pachychoroid disease spectrum abnormalities.Acta ophthalmologica · 2022Article
- Diffuse large B-cell lymphoma presenting as reversible intrapulmonary arteriovenous shunts with hypoxia, fever and progressive jaundice: a case report and literature review.BMC pulmonary medicine · 2022Review
- Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model.Journal of functional morphology and kinesiology · 2021Article
- Case Report: Intrapulmonary Arteriovenous Anastomoses in COVID-19-Related Pulmonary Vascular Changes: A New Player in the Arena?Frontiers in medicine · 2021Article
- Exercise-Induced Hypoxemia in Endurance Athletes: Consequences for Altitude Exposure.Frontiers in sports and active living · 2021Review
- Mechanisms of Hypoxia in COVID-19 Patients: A Pathophysiologic Reflection.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- AltitudeOmics: effect of reduced barometric pressure on detection of intrapulmonary shunt, pulmonary gas exchange efficiency, and total pulmonary resistance.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Hypoxemia in Lipoid Pneumonia: Role of Intrapulmonary Bronchopulmonary Anastomoses.American journal of respiratory and critical care medicine · 2017Article
- Reply from Jonathan E. Elliott, Joseph W. Duke, Jerold A. Hawn, John R. Halliwill and Andrew T. Lovering.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrapulmonary arteriovenous anastomoses (IPAVA) have been known to exist in human lungs for over 60 years. The majority of the work in this area has largely focused on characterizing the conditions in which IPAVA blood flow (Q̇IPAVA ) is either increased, e.g. during exercise, acute normobaric hypoxia, and the intravenous infusion of catecholamines, or absent/decreased, e.g. at rest and in all conditions with alveolar hyperoxia (FIO2 = 1.0). Additionally, Q̇IPAVA is present in utero and shortly after birth, but is reduced in older (>50 years) adults during exercise and with alveolar hypoxia, suggesting potential developmental origins and an effect of age. The physiological and pathophysiological roles of Q̇IPAVA are only beginning to be understood and therefore these data remain controversial. Although evidence is accumulating in support of important roles in both health and disease, including associations with pulmonary arterial pressure, and adverse neurological sequelae, there is much work that remains to be done to fully understand the physiological and pathophysiological roles of IPAVA. The development of novel approaches to studying these pathways that can overcome the limitations of the currently employed techniques will greatly help to better quantify Q̇IPAVA and identify the consequences of Q̇IPAVA on physiological and pathophysiological processes. Nevertheless, based on currently published data, our proposed working model is that Q̇IPAVA occurs due to passive recruitment under conditions of exercise and supine body posture, but can be further modified by active redistribution of pulmonary blood flow under hypoxic and hyperoxic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.