ArticleCell reports2015
Insights into the evolution of longevity from the bowhead whale genome.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers.
What it found
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Who cites it
204 citing papers in PubMed, 383 citations in OpenAlex.
- Epigenetic insights into extreme longevity in the world's oldest terrestrial animal, Jonathan.Science advances · 2026Article
- Adaptive Evolution of FOXO Family Regulating Lifespan Extension and Cancer Resistance in Long-Lived Species.Integrative zoology · 2026Article
- Structural decomposition enables multi-omics dissection of common and organ-specific aging.Science China. Life sciences · 2026Article
- Sensing Underwater: Diversifying Selection, Convergent Evolution and Inactivation in Sensory Receptors' Genes of Aquatic Mammals.Journal of molecular evolution · 2026Article
- Evolutionary convergence and niche-specific regulation of core HIF1A pathway genes synergistically drive divergent hypoxia adaptation in mammals.BMC ecology and evolution · 2026Article
- A Primate-Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1-Dependent Destabilization of RBMX.Aging cell · 2026Article
- Telomere biology and telomerase regulation across species: evolutionary insights into aging, longevity, and genome stability.Molecular biology reports · 2026Review
- Adaptive metabolic reprogramming conserves energy status in Antarctic giants.Scientific reports · 2026Article
- Convergence and Reducibility as Transferability Filters in Biomimetic Design.Journal of functional biomaterials · 2026Review
- Insights into a long life without cancer: The case of the bowhead whale.Molecular oncology · 2026Review
- A dual role for cGAS in shaping cellular and organismal responses to genomic instability.Genes & development · 2026Article
- Molecular Evidence for the Parallel Evolution of Anosmia in Multiple Odontoceti (Toothed Whales) Clades.Genes · 2026Article
- Tracing the Drivers of Range-Wide Bowhead Whale Genomic Structure and Diversity.Molecular ecology · 2026Article
- Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan.Nature aging · 2026Article
- The genomic basis of independent marine transitions in turtles: convergent episodic adaptation and demographic shifts.Molecular biology and evolution · 2026Article
- Pressure-tolerant Evolution in Rhodopsin of Deep-diving Whales.Genome biology and evolution · 2026Article
- Conserved Pathways, Divergent Outcomes: A Cross-Species Genomic Perspective on the Cancer-Neurodegeneration Paradox.International journal of molecular sciences · 2026Review
- A genomic compendium of hundreds of teleost fishes reveals their evolutionary landscape.Innovation (Cambridge (Mass.)) · 2026Article
- When cells rebel: a comparative genomics investigation into marsupial cancer susceptibility.Molecular biology and evolution · 2026Article
- Molecular divergence ofZoological research · 2026Article
144 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 17 institutions in 7 countries.
Funding
Abstract
The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.