ArticleJournal of the American Chemical Society2015
Virtually instantaneous, room-temperature [(11)C]-cyanation using biaryl phosphine Pd(0) complexes.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
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- Chalcogen-bridged coordination polymer for the photocatalytic activation of aryl halides.Nature communications · 2023Article
- Radiochemistry for positron emission tomography.Nature communications · 2023Review
- Room-Temperature Copper-Mediated Radiocyanation of Aryldiazonium Salts and Aryl Iodides via Aryl Radical Intermediates.Journal of the American Chemical Society · 2023Article
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- Strategic, feasibility, economic, and cultural aspects of phase 0 approaches: Is it time to change the drug development process in order to increase productivity?Clinical and translational science · 2022Review
- Synthesis and Characterization of 5-(2-Fluoro-4-[Journal of medicinal chemistry · 2022Article
- A Neophyl Palladacycle as an Air- and Thermally Stable Precursor to Oxidative Addition Complexes.Organic letters · 2021Article
- A Ligand Exchange Process for the Diversification of Palladium Oxidative Addition Complexes.Organic letters · 2021Article
- Radiosynthesis and preliminary evaluation ofTetrahedron letters · 2020Article
- Synthesis and evaluation of 6-(Bioorganic & medicinal chemistry letters · 2020Article
- Visualization of AMPA receptors in living human brain with positron emission tomography.Nature medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A new radiosynthetic protocol for the preparation of [(11)C]aryl nitriles has been developed. This process is based on the direct reaction of in situ prepared L·Pd(Ar)X complexes (L = biaryl phosphine) with [(11)C]HCN. The strategy is operationally simple, exhibits a remarkably wide substrate scope with short reaction times, and demonstrates superior reactivity compared to previously reported systems. With this procedure, a variety of [(11)C]nitrile-containing pharmaceuticals were prepared with high radiochemical efficiency.
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Registered trials
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