Evidence map›Paper›PMID 25565027›Full record

ArticleNature structural & molecular biology2015

Using synthetic RNAs as scaffolds and regulators.

Cameron Myhrvold, Pamela A Silver

Abstract read
PubMed Publisher
In one paragraph

Article in Nature structural & molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. RNA splicing in health and disease.Molecular biomedicine · 2026
    Review
  2. Article
  3. 3D RNA-scaffolded wireframe origami.Nature communications · 2023
    Article
  4. Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts.Frontiers in bioengineering and biotechnology · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Biomedical Applications of RNA-Based Devices.Current opinion in biomedical engineering · 2017
    Article
  11. Review
  12. Review
  13. Article
  14. Engineered transmembrane pores.Current opinion in chemical biology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cameron MyhrvoldDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA, and the Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
Pamela A SilverDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA, and the Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The natural versatility of RNA makes it an ideal substrate for bioengineering. Its structural properties and predictable base-pairing permit its use as molecular scaffold, and its ability to interact with nucleic acids, proteins and small molecules confers a regulatory potential that can be harvested to design RNA regulators in diverse contexts.

Indexed as

Base PairingBioengineeringNucleic Acid ConformationRNARNA

Identifiers

PMID25565027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.