ArticleBiophysical journal2015
Mechanical amplification exhibited by quiescent saccular hair bundles.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dynamics of Mechanically Coupled Hair-Cell Bundles of the Inner Ear.Biophysical journal · 2021Article
- A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction.Trends in neurosciences · 2019Review
- Voltage-Mediated Control of Spontaneous Bundle Oscillations in Saccular Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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2 authors.
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Abstract
Spontaneous oscillations exhibited by free-standing hair bundles from the Bullfrog sacculus suggest the existence of an active process that might underlie the exquisite sensitivity of the sacculus to mechanical stimulation. However, this spontaneous activity is suppressed by coupling to an overlying membrane, which applies a large mechanical load on the bundle. How a quiescent hair bundle utilizes its active process is still unknown. We studied the dynamics of motion of individual hair bundles under different offsets in the bundle position, and observed the occurrence of spikes in hair-bundle motion, associated with the generation of active work. These mechanical spikes can be evoked by a sinusoidal stimulus, leading to an amplified movement of the bundle with respect to the passive response. Amplitude gain reached as high as 100-fold at small stimulus amplitudes. Amplification of motion decreased with increasing amplitude of stimulation, ceasing at ∼6-12 pN stimuli. Results from numerical simulations suggest that the adaptation process, mediated by myosin 1c, is not required for the production of mechanical spikes.
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