Evidence map›Paper›PMID 25564621›Full record

ReviewDevelopment (Cambridge, England)2015

Establishing neural crest identity: a gene regulatory recipe.

Marcos Simões-Costa, Marianne E Bronner

Abstract readReview
In one paragraph

Review in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 361 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
361citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

361 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Genetics of Waardenburg Syndrome in Africa: A Systematic Review.International journal of molecular sciences · 2025
    Pooled it
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301 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marcos Simões-CostaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Marianne E BronnerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA mbronner@caltech.edu.

Funding

Integrating signaling and transcriptional control in neural crest specificationK99DE024232 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI SIMOES-COSTA, MARCOS · 2014 to 2015
$178k
NIDCR NIH HHS K99 DE024232
6 · The paper itself

Abstract

The neural crest is a stem/progenitor cell population that contributes to a wide variety of derivatives, including sensory and autonomic ganglia, cartilage and bone of the face and pigment cells of the skin. Unique to vertebrate embryos, it has served as an excellent model system for the study of cell behavior and identity owing to its multipotency, motility and ability to form a broad array of cell types. Neural crest development is thought to be controlled by a suite of transcriptional and epigenetic inputs arranged hierarchically in a gene regulatory network. Here, we examine neural crest development from a gene regulatory perspective and discuss how the underlying genetic circuitry results in the features that define this unique cell population.

Indexed as

Models, BiologicalAnimalsCell DifferentiationEpigenesis, GeneticGene Expression Regulation, DevelopmentalGene Regulatory NetworksNeural CrestVertebratesGene regulationMigrationNeural crestNeural plate borderSignalingTranscription factors

Identifiers

PMID25564621
PMCPMC4302844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.