ArticleThe Journal of clinical investigation1989
Plasma Ip(a) concentration is inversely correlated with the ratio of Kringle IV/Kringle V encoding domains in the apo(a) gene.
Article in The Journal of clinical investigation, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 156 citations in OpenAlex.
- Genetic coding variants in the niacin receptor, hydroxyl-carboxylic acid receptor 2, and response to niacin therapy.Pharmacogenetics and genomics · 2017Trial
- Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy.Atherosclerosis · 2009 · on this mapTrial
- Hormonal regulation of serum Lp (a) levels. Opposite effects after estrogen treatment and orchidectomy in males with prostatic carcinoma.The Journal of clinical investigation · 1992Trial
- Lipoprotein(a) and Effects of Diet: Time for Reassessment.Nutrients · 2025Review
- Lipoprotein(a) and Risk of Ischemic Stroke in the REGARDS Study.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Effect of Two Lipoprotein (a)-Associated Genetic Variants on Plasminogen Levels and Fibrinolysis.G3 (Bethesda, Md.) · 2016Article
- SCARB1 Gene Variants Are Associated With the Phenotype of Combined High High-Density Lipoprotein Cholesterol and High Lipoprotein (a).Circulation. Cardiovascular genetics · 2016Article
- A Case-Control Study of the Relationship Between SLC22A3-LPAL2-LPA Gene Cluster Polymorphism and Coronary Artery Disease in the Han Chinese Population.Iranian Red Crescent medical journal · 2016Article
- Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans.Journal of lipid research · 2016Review
- Lipoprotein (a): structure, pathophysiology and clinical implications.Arquivos brasileiros de cardiologia · 2014 · on this mapReview
- Scavenger receptor-BI is a receptor for lipoprotein(a).Journal of lipid research · 2013Article
- Association study of lipoprotein(a) genetic markers, traditional risk factors, and coronary heart disease in HIV-1-infected patients.Frontiers in immunology · 2012Article
- Lipoprotein(a): genotype-phenotype relationship and impact on atherogenic risk.Metabolic syndrome and related disorders · 2011Review
- Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.PloS one · 2011Article
- Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk.Stroke · 2011Article
- The apolipoprotein(a) gene: linkage disequilibria at three loci differs in African Americans and Caucasians.Atherosclerosis · 2008Article
- LPA and PLG sequence variation and kringle IV-2 copy number in two populations.Human heredity · 2008Article
- Comparison of false-discovery rate for genome-wide and fine mapping regions.BMC proceedings · 2007Article
- Lipoprotein(a): an elusive cardiovascular risk factor.Arteriosclerosis, thrombosis, and vascular biology · 2004Review
- Recent advances in molecular genetics of cardiovascular disorders. Implications for atherosclerosis and diseases of cellular lipid metabolism.Pathology oncology research : POR · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Plasma Lp(a) levels correlate with atherosclerosis susceptibility. This lipoprotein consists of an LDL-like particle attached to a large glycoprotein called apo(a). Apo(a) is a complex glycoprotein containing multiple Kringle domains, found to be highly homologous to plasminogen Kringle IV, and a single Kringle domain homologous to plasminogen Kringle V. Lp(a) levels appear to be inversely correlated with apo(a) size in a given individual. In this study, we have used probes specific to the Kringles IV and V domains of apo(a) cDNA in quantitative Southern blotting analysis. By this method, we have determined the ratio of Kringle IV/Kringle V encoding domains in the apo(a) gene of 53 unrelated individuals with different plasma concentrations of Lp(a). This ratio was found to be inversely correlated with log Lp(a) levels (r = -0.90, P less than 0.0001) and directly correlated with apo(a) apparent molecular weight (Mr) (r = 0.79, P less than 0.0001). In summary, by showing that Lp(a) concentrations and apo(a) apparent size are highly correlated with the ratio of Kringle IV/Kringle V encoding domains in the apo(a) gene, we provide a DNA marker for this atherosclerosis risk factor as well as an important insight into the genetic mechanism regulating Lp(a) levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.