ReviewCurrent pharmaceutical design2015
Childhood maltreatment and stress-related psychopathology: the epigenetic memory hypothesis.
Review in Current pharmaceutical design, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Experiences of Trauma and DNA Methylation Profiles among African American Mothers and Children.International journal of molecular sciences · 2022Article
- Modeling heritability of temperamental differences, stress reactivity, and risk for anxiety and depression: Relevance to research domain criteria (RDoC).The European journal of neuroscience · 2022Review
- Associations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples.Frontiers in cell and developmental biology · 2022Article
- Molecular impacts of childhood abuse on the human brain.Neurobiology of stress · 2021Review
- Addressing Intersecting Social and Mental Health Needs Among Transition-Age Homeless Youths: A Review of the Literature.Psychiatric services (Washington, D.C.) · 2021Review
- Early Enriched Environment Prevents Epigenetic p11 Gene Changes Induced by Adulthood Stress in Mice.International journal of molecular sciences · 2021Article
- Children With Disruptive Mood Dysregulation Disorder and Psychopathological Risk in Their Mothers: The Function of Global DNA Methylation.Frontiers in psychiatry · 2021Article
- The Role of Epigenetic Dysregulation in Suicidal Behaviors.Current topics in behavioral neurosciences · 2020Article
- Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma.Frontiers in psychiatry · 2019Review
- Bridging Basic and Clinical Research in Early Life Adversity, DNA Methylation, and Major Depressive Disorder.Frontiers in genetics · 2019Review
- A pilot investigation on DNA methylation modifications associated with complex posttraumatic symptoms in elderly traumatized in childhood.BMC research notes · 2017Article
- Tracking the evolution of epialleles during neural differentiation and brain development: D-Aspartate oxidase as a model gene.Epigenetics · 2017Article
- Childhood adversities and distress - The role of resilience in a representative sample.PloS one · 2017Article
- A Slice of the Suicidal Brain: What Have Postmortem Molecular Studies Taught Us?Current psychiatry reports · 2016Review
- Investigating epigenetic consequences of early-life adversity: some methodological considerations.European journal of psychotraumatology · 2016Article
- Childhood maltreatment and methylation of FK506 binding protein 5 gene (FKBP5).Development and psychopathology · 2015Article
- Towards a Role for Clinical Pathology Diagnostics for Childhood Maltreatment.Austin journal of clinical pathologyArticle
- An Epigenetics-Based, Lifestyle Medicine-Driven Approach to Stress Management for Primary Patient Care: Implications for Medical Education.American journal of lifestyle medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Childhood maltreatment (CM) is all too frequent among western societies, with an estimated prevalence of 10 to 15%. CM associates with increased risk of several psychiatric disorders, and therefore represents a worrying public and socioeconomic burden. While associated clinical outcomes are well characterized, determining by which mechanisms early-life adverse experiences affect mental health over the lifespan is a major challenge. Epigenetic mechanisms, in particular DNA methylation, represent a form of molecular memory that may modify brain function over extended periods of time, as well as serve as a bio-marker of behavioral phenotypes associated with CM. Here, we review human studies suggesting that DNA methylation is a crucial substrate mediating neurobiological consequences of CM throughout life, thereby potentiating maladaptive behavioral patterns and psychopathological risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.