Evidence map›Paper›PMID 25564368›Full record

ArticleJournal of exposure science & environmental epidemiology

Nrf2-related gene expression and exposure to traffic-related air pollution in elderly subjects with cardiovascular disease: An exploratory panel study.

Sharine Wittkopp, Norbert Staimer, Thomas Tjoa, Timothy Stinchcombe, Nancy Daher, James J Schauer, Martin M Shafer, Constantinos Sioutas, Daniel L Gillen, Ralph J Delfino

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Harnessing Evolution and Biomimetics to Enhance Planetary Health: Kidney Insights.Journal of the American Society of Nephrology : JASN · 2025
    Review
  3. Article
  4. Longitudinal changes in cardiovascular disease-related proteins in welders.International archives of occupational and environmental health · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Semi-volatile components of PMAtmospheric environment (Oxford, England : 1994) · 2020
    Article
  14. Review
  15. Article
  16. Article
  17. Zebrafish Locomotor Responses Reveal Irritant Effects of Fine Particulate Matter Extracts and a Role for TRPA1.Toxicological sciences : an official journal of the Society of Toxicology · 2018
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sharine WittkoppOccupational and Environmental Medicine Division, Department of Medicine, School of Medicine, University of California, Irvine (UCI), Irvine, California, USA.
Norbert StaimerDepartment of Epidemiology, School of Medicine, UCI, Irvine, California, USA.
Thomas TjoaDepartment of Epidemiology, School of Medicine, UCI, Irvine, California, USA.
Timothy StinchcombeIntrexon Corp., Blacksburg, Virginia, USA.
Nancy DaherDepartment of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA.
James J SchauerUniversity of Wisconsin-Madison, Environmental Chemistry and Technology Program, Madison, Wisconsin, USA.
Martin M ShaferUniversity of Wisconsin-Madison, Environmental Chemistry and Technology Program, Madison, Wisconsin, USA.
Constantinos SioutasDepartment of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA.
Daniel L GillenDepartment of Statistics, School of Information and Computer Sciences, UCI, Irvine, California, USA.
Ralph J DelfinoDepartment of Epidemiology, School of Medicine, UCI, Irvine, California, USA.
University of California, Irvine · USUniversity of Southern California · USUniversity of Wisconsin–Madison · USExxonMobil (United States) · US

Funding

ZOVIRAX CREAM TO TREAT HERPES LABIALIS IN ADOLESCENTSM01RR000827 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, R JEFFREY · 1985 to 2010
$74.3M
Ultrafine Particulate Matter &Cardiorespiratory HealthR01ES012243 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DELFINO, RALPH J · 2003 to 2015
$6.0M
Air Pollution and Peripheral Blood Gene Expression in Subjects with Coronary ArteR21ES016420 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DELFINO, RALPH J · 2009 to 2010
$412k
Gene expression responses to air pollution and modification by genetic variationF30ES021107 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI WITTKOPP, SHARINE · 2012 to 2015
$169k
NCRR NIH HHS M01 RR000827NCRR NIH HHS MO1-RR00827NIEHS NIH HHS F30 ES021107NIEHS NIH HHS F30 ES21107NIEHS NIH HHS R01 ES012243NIEHS NIH HHS R01-ES12243NIEHS NIH HHS R21 ES016420NIEHS NIH HHS R21-ES016420
6 · The paper itself

Abstract

Gene expression changes are linked to air pollutant exposures in in vitro and animal experiments. However, limited data are available on how these outcomes relate to ambient air pollutant exposures in humans. We performed an exploratory analysis testing whether gene expression levels were associated with air pollution exposures in a Los Angeles area cohort of elderly subjects with coronary artery disease. Candidate genes (35) were selected from published studies of gene expression-pollutant associations. Expression levels were measured weekly in 43 subjects (≤ 12 weeks) using quantitative PCR. Exposures included gaseous pollutants O3, nitrogen oxides (NOx), and CO; particulate matter (PM) pollutants elemental and black carbon (EC, BC); and size-fractionated PM mass. We measured organic compounds from PM filter extracts, including polycyclic aromatic hydrocarbons (PAHs), and determined the in vitro oxidative potential of particle extracts. Associations between exposures and gene expression levels were analyzed using mixed-effects regression models. We found positive associations of traffic-related pollutants (EC, BC, primary organic carbon, PM 0.25-2.5 PAH and/or PM 0.25 PAH, and NOx) with NFE2L2, Nrf2-mediated genes (HMOX1, NQO1, and SOD2), CYP1B1, IL1B, and SELP. Findings suggest that NFE2L2 gene expression links associations of traffic-related air pollution with phase I and II enzyme genes at the promoter transcription level.

Indexed as

AgedAged, 80 and overAir PollutantsAir PollutionCardiovascular DiseasesCohort StudiesCoronary Artery DiseaseCytochrome P-450 CYP1B1Environmental MonitoringFemaleGene ExpressionGenetic MarkersHumansLos AngelesMaleNF-E2-Related Factor 2Air PollutantsCYP1B1 protein, humanCytochrome P-450 CYP1B1Genetic MarkersNFE2L2 protein, humanNF-E2-Related Factor 2Particulate MatterP-SelectinSELP protein, humanSootVehicle Emissions

Identifiers

PMID25564368
PMCPMC4495007
OpenAlexW2059686197

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.