Evidence map›Paper›PMID 25564234›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015

Blood flow distribution in cerebral arteries.

Laleh Zarrinkoob, Khalid Ambarki, Anders Wåhlin, Richard Birgander, Anders Eklund, Jan Malm

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 1 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 1 synthesis or guideline pooled it, 347 citations in OpenAlex.

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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Laleh ZarrinkoobDepartment of Clinical Neuroscience, Umeå University, Umeå, Sweden.
Khalid Ambarki1] Department of Radiation Sciences, Umeå University, Umeå, Sweden [2] Centre for Biomedical Engineering and Physics, Umeå University, Umeå, Sweden.
Anders Wåhlin1] Department of Radiation Sciences, Umeå University, Umeå, Sweden [2] Umeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
Richard BirganderDepartment of Radiation Sciences, Umeå University, Umeå, Sweden.
Anders Eklund1] Department of Radiation Sciences, Umeå University, Umeå, Sweden [2] Centre for Biomedical Engineering and Physics, Umeå University, Umeå, Sweden.
Jan MalmDepartment of Clinical Neuroscience, Umeå University, Umeå, Sweden.
Umeå University · SECentre for Biomedical Engineering and Physics · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-resolution phase-contrast magnetic resonance imaging can now assess flow in proximal and distal cerebral arteries. The aim of this study was to describe how total cerebral blood flow (tCBF) is distributed into the vascular tree with regard to age, sex and anatomic variations. Forty-nine healthy young (mean 25 years) and 45 elderly (mean 71 years) individuals were included. Blood flow rate (BFR) in 21 intra- and extracerebral arteries was measured. Total cerebral blood flow was defined as BFR in the internal carotid plus vertebral arteries and mean cerebral perfusion as tCBF/brain volume. Carotid/vertebral distribution was 72%/28% and was not related to age, sex, or brain volume. Total cerebral blood flow (717 ± 123 mL/min) was distributed to each side as follows: middle cerebral artery (MCA), 21%; distal MCA, 6%; anterior cerebral artery (ACA), 12%, distal ACA, 4%; ophthalmic artery, 2%; posterior cerebral artery (PCA), 8%; and 20% to basilar artery. Deviating distributions were observed in subjects with 'fetal' PCA. Blood flow rate in cerebral arteries decreased with increasing age (P<0.05) but not in extracerebral arteries. Mean cerebral perfusion was higher in women (women: 61 ± 8; men: 55 ± 6 mL/min/100 mL, P<0.001). The study describes a new method to outline the flow profile of the cerebral vascular tree, including reference values, and should be used for grading the collateral flow system.

Indexed as

Cerebrovascular CirculationAdultAgedAgingBlood Flow VelocityBrainCerebral ArteriesCircle of WillisFemaleHemodynamicsHumansMagnetic Resonance ImagingMaleYoung Adult

Identifiers

PMID25564234
PMCPMC4420884
OpenAlexW2042621618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.