Evidence map›Paper›PMID 25564208›Full record

ReviewPflugers Archiv : European journal of physiology2015

Salt and osmosensing: role of cytoplasmic hydrogel.

Ryszard Grygorczyk, Francis Boudreault, Aleksandra Platonova, Sergei N Orlov

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. PIEZO channels as multimodal mechanotransducers.Biochemical Society transactions · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ryszard GrygorczykCentre de Recherche, Centre Hospitalier de l'Université de Montréal (CRCHUM)-Tour Viger, 900, rue St-Denis, Montreal, Quebec, Canada, H2X 0A9, Ryszard.Grygorczyk@umontreal.ca.
Francis Boudreault
Aleksandra Platonova
Sergei N Orlov

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osmotic perturbations, occurring frequently under physiological and pathological conditions, alter cell size/volume and function. To protect cellular homeostasis, cell osmo- and volume-sensing mechanisms activate volume compensatory processes. The plasma membrane plays a prominent role in cell volume regulation by mediating the selective transport of extra- and intracellular osmolytes. The function of the membrane-enclosed cytoplasm in osmosensing and cell volume homeostasis is much less appreciated. We present current concepts and discuss evidence of cell volume sensors with emphasis on the hydrogel nature of the mammalian cytoplasm and its intrinsic osmosensitivity.

Indexed as

OsmoregulationAnimalsCell MembraneCell SizeCytoplasmHumansHydrogelsSingle-Cell AnalysisSodiumHydrogelsSodium

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.