ReviewAnnals of surgical oncology2015
Additional Primary Malignancies in Patients with Gastrointestinal Stromal Tumor (GIST): A Clinicopathologic Study of 260 Patients with Molecular Analysis and Review of the Literature.
Review in Annals of surgical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- The association of genitourinary cancer among Saudi patients with gastrointestinal stromal tumors and a systematic literature review.Scientific reports · 2023Pooled it
- Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia.World journal of gastroenterology · 2019Pooled it
- Paired tumor-normal targeted sequencing supports clonal independence of multiple primary malignancies in patients with gastrointestinal stromal tumors.International journal of clinical oncology · 2026Article
- Precision therapeutic strategies for advanced gastrointestinal stromal tumors.Cancer metastasis reviews · 2026Review
- The Prediagnostic General Practitioners' Pathway of Gastrointestinal Stromal Tumor Patients: A Real-World Data Study.Cancers · 2025Article
- Understanding Gastric GIST: From Pathophysiology to Personalized Treatment.Journal of clinical medicine · 2024Review
- Guideline-Based Follow-Up Outcomes in Patients With Gastrointestinal Stromal Tumor With Low Risk of Recurrence: A Report From the Italian Sarcoma Group.JAMA network open · 2023Article
- Article
- A review of NTRK fusions in cancer.Annals of medicine and surgery (2012) · 2022Review
- Primary pulmonary T-cell lymphoma after operation for small intestinal stromal tumor: A case report.Frontiers in oncology · 2022Article
- Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience.Medicina (Kaunas, Lithuania) · 2021Article
- Outcome of 1000 Patients With Gastrointestinal Stromal Tumor (GIST) Treated by Surgery in the Pre- and Post-imatinib Eras.Annals of surgery · 2021Article
- Association Between Gastrointestinal Stromal Tumors and Other Malignancies: It Is Only a Matter of Time ? A Case Series and an Overview of Systematic Reviews.Journal of gastrointestinal cancer · 2020Article
- Long-term survival among patients with gastrointestinal stromal tumors diagnosed after another malignancy: a SEER population-based study.World journal of surgical oncology · 2020Article
- Acute myeloid leukemia with t(11;19)(q23;p13.1) in a patient with a gastrointestinal stromal tumor undergoing imatinib therapy: A case report.World journal of clinical cases · 2020Article
- Malignancies associated with GIST: a retrospective study with molecular analysis of KIT and PDGFRA.Langenbeck's archives of surgery · 2019Article
- Additional malignancies in patients with gastrointestinal stromal tumors (GIST): incidence, pathology and prognosis according to a time of occurrence-based classification.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Article
- Intra-abdominal desmoid tumors mimicking gastrointestinal stromal tumors - 8 cases: A case report.World journal of gastroenterology · 2019Article
- A correlation research of Ki67 index, CT features, and risk stratification in gastrointestinal stromal tumor.Cancer medicine · 2018Article
- Mesenteric fibromatosis after resection for gastrointestinal stromal tumor of stomach: A case report.Medicine · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe incidence of other primary neoplasms in gastrointestinal stromal tumor (GIST) patients is relatively high. Our aim was to better characterize the clinicopathologic and molecular relationships in a cohort of GIST patients.
methodsAll GIST patients with tumor samples sent for molecular testing were identified via electronic medical records. Clinicopathologic characteristics of GIST and additional primary malignancies were analyzed.
resultsOf 260 patients, 50 (19 %) had at least one additional primary malignancy. In 33 patients, separate primary neoplasms predated their GIST diagnosis and most commonly included: prostate (n = 9), breast (n = 8), and hematologic (n = 5). Renal (n = 4) and hematologic (n = 3) malignancies were the most frequent cancers identified after GIST diagnosis. The majority (8 of 12, 66 %) of malignancies diagnosed after GIST were found incidentally. Patients who developed other malignancies after GIST more often had KIT exon 11 mutations (100 vs. 66 %, P = 0.01). In comparison to patients with only GIST, patients with a second primary neoplasm of any chronology had GISTs with increased mitotic rate (≥5 per 50 high-power fields) (P = 0.0006). Literature review revealed colorectal cancer, gastric, prostate, renal, leukemia, and desmoid-type fibromatosis as the most common secondary neoplasms.
conclusionsNineteen percent of GIST patients develop other malignancies. This is the first report to describe a relationship between additional primary malignancy and both mutation and mitotic rate of GIST. Although the basis of these relationships remains to be investigated, caution in the clinical management of GIST patients with additional lesions is warranted.
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