ArticleClinical oral investigations2015
Hypertension modifies OPG, RANK, and RANKL expression during the dental socket bone healing process in spontaneously hypertensive rats.
Article in Clinical oral investigations, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Identifying risk factors for osteoradionecrosis of the jaws: a systematic review and meta-analysis.Clinical oral investigations · 2026Pooled it
- Prevalence, incidence, systemic, behavioral, and patient-related risk factors and indicators for peri-implant diseases: An AO/AAP systematic review and meta-analysis.Journal of periodontology · 2025Pooled it
- Do antihypertensive medications have an effect on dental implants? A systematic review.Oral and maxillofacial surgery · 2024Pooled it
- The key role of RANKL and OPG as molecular biomarkers in bone remodeling associated with different grafts regarding socket preservation: A systematic review.Journal of Taibah University Medical Sciences · 2026Review
- Investigation of the effect of obesity on trabecular and cortical bone structure in the peri-implant region using fractal analysis and radiomorphometric indices.BMC medical imaging · 2026Article
- Article
- [Analysis of risk factors for early failure of simple taper retentive implants].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025Article
- A preliminary study of cell-based bone tissue engineering into 3D-printed β-tricalcium phosphate scaffolds and polydioxanone membranes.Scientific reports · 2024Article
- Combination of a Synthetic Bioceramic Associated with a Polydioxanone-Based Membrane as an Alternative to Autogenous Bone Grafting.Biomimetics (Basel, Switzerland) · 2024Article
- Hypertension and Dental Implants: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Analysis of peri-implant bone tissue between hydrophilic and rough implant surfaces in spontaneously hypertensive rats treated with losartan.Journal of applied oral science : revista FOB · 2024Article
- Ozone therapy improves early stages of osseointegration in ovariectomized rats.Journal of applied oral science : revista FOB · 2024Article
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- Article
- Performance of Polydioxanone-Based Membrane in Association with 3D-Printed Bioceramic Scaffolds in Bone Regeneration.Polymers · 2022Article
- The impact of medication on osseointegration and implant anchorage in bone determined using removal torque-A review.Heliyon · 2022Article
- Effect of Topical PTH 1-34 Functionalized to BiogranMaterials (Basel, Switzerland) · 2021Article
- The effects of calcitonin on post-orthodontic relapse in rats.Clinical and experimental dental research · 2021Article
- Impact of renin-angiotensin system inhibitors and beta-blockers on dental implant stability.International journal of implant dentistry · 2021Article
- Different Cell and Tissue Behavior of Micro-/Nano-Tubes and Micro-/Nano-Nets Topographies on Selective Laser Melting Titanium to Enhance Osseointegration.International journal of nanomedicine · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to evaluate the dental socket bone healing process by histomorphometric and immunohistochemical analysis of osteoprotegerin (OPG), receptor activator of nuclear factor-κβ (RANK), and receptor activator of nuclear factor-κβ ligand (RANKL) proteins in spontaneously hypertensive rats (SHR). MATERIALS AND
methodsUnder general anesthesia, 25 Wistar rats and 25 SHRs underwent upper right incisor extraction. Rats were euthanized after 7, 14, 21, 28, or 42 days of dental extractions. Histomorphometric and immunohistochemical analyses of OPG, RANK, and RANKL proteins were performed.
resultsHistomorphometric results showed decreased bone healing and reduced bone trabecular thickness in SHRs. Immunohistochemical reactions showed intense RANKL and RANK immunolabeling at 14 and 28 postoperative days and mild OPG immunolabeling at 7, 14, and 21 days after surgery in SHRs.
conclusionThe results of this study show that RANK, RANKL, and OPG immunolabeling was altered in SHRs, and these results are associated with bone healing delay and decreased trabecular thickness in SHRs. CLINICAL RELEVANCE: Hypertension alters the expression of RANK, RANKL, and OPG and delays the socket bone healing process. These alterations could influence some dental procedures such as orthodontic treatment and implant placement.
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