ArticleClinical and experimental medicine2016
Telomere length in non-neoplastic gastric mucosa and its relationship to H. pylori infection, degree of gastritis, and NSAID use.
Article in Clinical and experimental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Gastric microbiome in gastric cancer sequence depicts diverse microbial structures associated with cancer risk and prognosis.Journal of translational medicine · 2025Article
- Accelerated biological aging mediates the association between inflammatory markers with Helicobacter pylori infection and mortality.Journal of translational medicine · 2025Article
- Association of leukocyte telomere length with the risk of digestive diseases: A large-scale cohort study.Chinese medical journal · 2025Article
- Chronic inflammation and the hallmarks of aging.Molecular metabolism · 2023Review
- Pathogen burden and leukocyte telomere length in the United States.Immunity & ageing : I & A · 2020Article
- Analysis of Telomere Lengths in p53 Signatures and Incidental Serous Tubal Intraepithelial Carcinomas Without Concurrent Ovarian Cancer.The American journal of surgical pathology · 2019Article
- Telomere Shortening in the Alzheimer's Disease Neuroimaging Initiative Cohort.Journal of Alzheimer's disease : JAD · 2019Article
- Telomere length in the gastric mucosa after Helicobacter pylori eradication and its potential role in the gastric carcinogenesis.Clinical and experimental medicine · 2018Article
- Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer.Oncology letters · 2017Article
- Magnifying narrow-band imaging of gastric mucosal morphology predicts the H. pylori-related epigenetic field defect.Scientific reports · 2017Article
- Demonstration of potential link between Helicobacter pylori related promoter CpG island methylation and telomere shortening in human gastric mucosa.Oncotarget · 2016Article
- Telomere length shortening in gastric mucosa is a field effect associated with increased risk of gastric cancer.Virchows Archiv : an international journal of pathology · 2016Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomere shortening occurs with human aging in many organs and tissues and is accelerated by rapid cell turnover and oxidative injury. We measured average telomere length using quantitative real-time PCR in non-neoplastic gastric mucosa and assessed its relationship to H. pylori-related gastritis, DNA methylation, ulcer disease, and nonsteroidal anti-inflammatory drug (NSAID) usage. Gastric biopsies were obtained from 151 cancer-free subjects including 49 chronic NSAID users and 102 nonusers. Relative telomere length in genomic DNA was measured by real-time PCR. H. pylori infection status, histological severity of gastritis, and serum pepsinogens (PGs) were also investigated. E-cadherin (CDH1) methylation status was determined by methylation-specific PCR (MSP). Average relative telomere length of H. pylori-infected subjects was significantly shortened when compared to H. pylori-negative subjects (p = 0.002) and was closely associated with all histological parameter of gastritis (all p values <0.01) and CDH1 methylation (p = 0.0002). In H. pylori-negative subjects, NSAID users presented significantly shorter telomere length than nonusers (p = 0.028). Shorter telomere length was observed in duodenal and gastric ulcer patients compared with non-ulcer subjects among NSAID users. Telomere shortening is closely associated with severity of H. pylori-induced gastritis and CDH1 methylation status. Also, telomere shortening is accelerated by NSAID usage especially in H. pylori-negative subjects.
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