ArticleJournal of assisted reproduction and genetics2015
Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement.
Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Early-to-Mid-Luteal Serum Estradiol Levels with the Outcomes of Hormone Replacement Therapy-Frozen Embryo Transfer: A Systematic Review and Meta-Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Pooled it
- Evaluation of the functional role of corpus luteum cavity in recipient selection for bovine embryo transfer.Animal bioscience · 2026Article
- High level of estrogen on the day before embryo transfer is associated with reduced live birth after frozen embryo transfer: a retrospective cohort study from 14565 cycles.Frontiers in endocrinology · 2026Article
- Elevated estradiol levels in frozen embryo transfer have different effects on pregnancy outcomes depending on the stage of transferred embryos.Scientific reports · 2022Article
- Identification of the Metabolomics Signature of Human Follicular Fluid from PCOS Women with Insulin Resistance.Disease markers · 2022Article
- Does high estrogen level negatively affect pregnancy success in frozen embryo transfer?Archives of medical science : AMS · 2022Article
- Progesterone and estrogen levels are associated with live birth rates following artificial cycle frozen embryo transfers.Journal of assisted reproduction and genetics · 2021Article
- Serum progesterone levels greater than 32.5 ng/ml on the day of embryo transfer are associated with lower live birth rate after artificial endometrial preparation: a prospective study.Reproductive biology and endocrinology : RB&E · 2021Observational
- Multifactor Prediction of Embryo Transfer Outcomes Based on a Machine Learning Algorithm.Frontiers in endocrinology · 2021Article
- Design and evaluation of a novel nanodrug delivery system for reducing the side effects of clomiphene citrate on endometrium.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020Article
- Impact of Serum Estradiol Levels Prior to Progesterone Administration in Artificially Prepared Frozen Embryo Transfer Cycles.Frontiers in endocrinology · 2020Article
- Does Serum Estradiol Prior to Progesterone Administration in Programmed Frozen Embryo Transfer Cycle Impacts Live Birth Rate: A Prospective Cohort Study.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the impact of late follicular phase serum estradiol (E2) levels on implantation and pregnancy outcomes of cleavage stage cryopreserved/thawed embryos transferred in programmed cycles with exogenous hormonal replacement.
methodsRetrospective cohort analysis of IVF patients with transfer of cryopreserved-thawed day-3 embryos in E2 and progesterone (P4) supplemented cycles (n = 208 cycles).
main outcome measuresimplantation and pregnancy rates according to late follicular phase serum E2 levels and early secretory phase E2/P4 ratios.
resultsLogistic regression performed for embryo implantation and for pregnancy outcome in relation to E2 (day 15), P4 (day 15 and 16), before (crude analysis) and after adjustment (adjusted analysis) for baseline characteristics (including age, BMI, serum basal cycle day 3 FSH levels, embryo quality, endometrial lining thickness) showed no significant association. Similarly, ROC analysis showed no impact of cycle day 16 E2/P4 ratio.
conclusionsNeither late follicular phase serum E2 nor the early E2/P4 ratio were able to predict implantation or pregnancy outcome of day-3 cryopreserved-thawed embryos transferred in artificially programmed cycles.
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