Evidence map›Paper›PMID 25563434›Full record

ArticleEpidemiology (Cambridge, Mass.)2015

Risk of myocardial infarction immediately after alcohol consumption.

Elizabeth Mostofsky, Johanna G van der Bom, Kenneth J Mukamal, Malcolm Maclure, Geoffrey H Tofler, James E Muller, Murray A Mittleman

Open access · greenAbstract read
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Acute myocardial infarction in adolescents: reappraisal of underlying mechanisms.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2020
    Review
  7. Article
  8. Acute triggers of myocardial infarction: A case-crossover study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2017
    Article
  9. Article
  10. Review
  11. Article
  12. Alcohol Binge Drinking-Induced ST-Segment-Elevation Acute Coronary Syndrome.Journal of investigative medicine high impact case reports
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Elizabeth MostofskyFrom the aCardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA; bDepartment of Epidemiology, Harvard School of Public Health, Boston, MA; cDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; dCenter for Clinical Transfusion Research, Sanquin Research, Leiden, The Netherlands; eDivision of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA; fDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada; gDepartment of Cardiology, Royal North Shore Hospital, Sydney, Australia; and hInfraReDx, Burlington, MA.
Johanna G van der Bom
Kenneth J Mukamal
Malcolm Maclure
Geoffrey H Tofler
James E Muller
Murray A Mittleman
Beth Israel Deaconess Medical Center · USRoyal North Shore Hospital · AUSanquin · NLUniversity of British Columbia · CA

Funding

TRIGGERS OF VENTRICULAR ARRHYTHMIAS (TOVA) STUDYR01HL041016 · NHLBI · UNIVERSITY OF KENTUCKY · PI ALBERT, CHRISTINE M · 1989 to 2002
$1.6M
Bereavement and Cardiovascular Events: A Nationwide Prospective Study in SwedenF32HL120505 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MOSTOFSKY, ELIZABETH · 2013 to 2013
$54k
NHLBI NIH HHS F32 HL120505NHLBI NIH HHS HL-120505NHLBI NIH HHS HL-41016NHLBI NIH HHS L30 HL115623NHLBI NIH HHS R01 HL041016
6 · The paper itself

Abstract

backgroundHabitual moderate alcohol consumption is associated with a lower risk of acute myocardial infarction (MI), whereas heavy (binge) drinking is associated with higher cardiovascular risk. However, less is known about the immediate effects of alcohol consumption on the risk of acute MI and whether any association differs by beverage type or usual drinking patterns.

methodsWe conducted a case-crossover analysis of 3869 participants from the Determinants of Myocardial Infarction Onset Study who were interviewed during hospitalization for acute MI in one of the 64 medical centers across the United States in 1989-1996. We compared the observed number of times that each participant consumed wine, beer, or liquor in the hour preceding MI symptom onset with the expected frequency based on each participant's control information, defined as the number of times the participant consumed alcohol in the past year.

resultsAmong 3869 participants, 2119 (55%) reported alcohol consumption in the past year, including 76 within 1 hour before acute MI onset. The incidence rate of acute MI onset was elevated 1.72-fold (95% confidence interval [CI] = 1.37-2.16) within 1 hour after alcohol consumption. The association was stronger for liquor than for beer or wine. The higher rate was not apparent for daily drinkers. For the 24 hours after consumption, there was a 14% lower rate (relative risk = 0.86 [95% CI = 0.79-0.95]) of MI compared with periods with no alcohol consumption.

conclusionsAlcohol consumption is associated with an acutely higher risk of MI in the subsequent hour among people who do not typically drink alcohol daily.

Indexed as

AdultAgedAlcohol DrinkingAlcoholic BeveragesCase-Control StudiesFemaleHumansIncidenceMaleMiddle AgedMyocardial InfarctionRisk FactorsUnited States

Identifiers

PMID25563434
PMCPMC4314445
OpenAlexW2318624301

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.