ArticleEuropean journal of medical research2015
An immunohistochemical study of CD83- and CD1a-positive dendritic cells in the decidua of women with recurrent spontaneous abortion.
Article in European journal of medical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Cross-talk between mitophagy pathways in pre-eclampsia and gestational diabetes mellitus: a systematic analysis of shared molecular mechanisms.European journal of medical research · 2025Article
- The Relationship Between Gut Microbiota and Recurrent Spontaneous Abortion.Microorganisms · 2025Review
- A Review of Immunological Evaluation of Patients with Recurrent Spontaneous Abortion (RSA).International journal of molecular sciences · 2025Review
- Identification and validation of paraptosis-related biomarkers in recurrent miscarriage.Frontiers in immunology · 2025Article
- Review
- Differential Expression and Prognostic Correlation of Immune Related Factors Between Right and Left Side Colorectal Cancer.Frontiers in oncology · 2022Article
- Molecular subtype identification and predictive power of N6-methyladenosine regulator in unexplained recurrent pregnancy loss.Frontiers in genetics · 2022Article
- Recurrent implantation failure: A comprehensive summary from etiology to treatment.Frontiers in endocrinology · 2022Review
- The Role of Immune Cells in Recurrent Spontaneous Abortion.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Gestational Diabetes Mellitus and Maternal Immune Dysregulation: What We Know So Far.International journal of molecular sciences · 2021Review
- Endometrial Immune Dysfunction in Recurrent Pregnancy Loss.International journal of molecular sciences · 2019Review
- Endocervical trophoblast for interrogating the fetal genome and assessing pregnancy health at five weeks.European journal of medical genetics · 2019Article
- Cystic and solitary nodular pulmonary metastases in a patient with low-grade endometrial stromal sarcoma: A case report and literature review.Oncology letters · 2019Article
- Human Miscarriage Is Associated With Dysregulations in Peripheral Blood-Derived Myeloid Dendritic Cell Subsets.Frontiers in immunology · 2019Article
- Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface.Frontiers in immunology · 2019Review
- Human endometrial stromal cell decidualization requires transcriptional reprogramming by PLZF.Biology of reproduction · 2018Article
- Immune Modulatory Effects of Human Chorionic Gonadotropin on Dendritic Cells Supporting Fetal Survival in Murine Pregnancy.Frontiers in endocrinology · 2016Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are more and more women with recurrent spontaneous abortion (RSA). The mechanism of RSA is still unclear. Immunological factors have been postulated to play a role in the etiology of RSA. Dendritic cells (DCs) are the most potent antigen-presenting cells in the immune system, and the decidual DCs may take part in the occurrence of RSA. The difference in maturity status of decidual DCs among women with RSA and women with normal pregnancies is worthy of studying for its application to prevention and therapy.
methodsThe EnVision two-step immunohistochemical staining technique was used to detect the expression of CD83 and CD1a in the decidua of women with RSA (30 cases) and normal pregnancies (30 cases). The maturity status, distribution and quantity of DCs in the two groups were observed. Observation of the staining and cell counting were done using microscope within 30 randomly selected high-power fields (HPF, 40 × 10). All data analyses were conducted with SPSS 17.0 and the statistical significance was set at P <0.05.
resultsThe decidua from the two groups contained DCs that stained with the anti-CD83 and anti-CD1a antibody. Most of the decidual CD83(+)DCs from two groups were located in the stroma. There were more CD83(+)DCs clustered with other DCs in the stroma from women with RSA than normal pregnancies. Most of the CD1a(+)DCs in the decidua from the two groups are located close to maternal glandular epithelium. No difference in the location of CD1a(+)DCs was found in the decidua between two groups. The number of decidual CD83(+)DCs was statistically significantly higher in RSA women than in normal early pregnant women (14.20 ± 13.34/30 HPF versus 4.77 ± 2.64/30 HPF; t = 3.800, P = 0.001). The number of CD1a(+)DCs in the decidua was statistically significantly lower in RSA women compared with normal early pregnant women (3.97 ± 3.75/30 HPF versus 7.60 ± 6.08/30 HPF; t = 2.786, P = 0.008).
conclusionsThese findings suggest that the increase in the number of mature DCs and the decrease in the quantity of immature DCs in the decidua may be related to RSA. The maturation of decidual DCs may play an important role in the pathogenesis of RSA.
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