ArticlePsychopharmacology2015
Monetary discounting and ventral striatal dopamine receptor availability in nontreatment-seeking alcoholics and social drinkers.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Personalized Virtual Reality Future Selves Elicit Introspective Brain Activation in Early Substance Use Disorder Recovery.medRxiv : the preprint server for health sciences · 2026Article
- Personalized Virtual Reality Future Selves Elicit Introspective Brain Activation in Early Substance Use Disorder Recovery.Substance abuse and rehabilitation · 2026Article
- Delay discounting and alcohol consumption correlate with dorsal anterior insula activation during choice in nontreatment-seeking heavy drinkers.Alcoholism, clinical and experimental research · 2022Article
- Virtual reality intervention effects on future self-continuity and delayed reward preference in substance use disorder recovery: pilot study results.Discover mental health · 2022Article
- Mapping cortical and subcortical asymmetries in substance dependence: Findings from the ENIGMA Addiction Working Group.Addiction biology · 2021Article
- Brain responses during delay discounting in youth at high-risk for substance use disorders.NeuroImage. Clinical · 2021Article
- Brain responses to anticipating and receiving beer: Comparing light, at-risk, and dependent alcohol users.Addiction biology · 2020Article
- The monoamine stabilizer (-)-OSU6162 prevents the alcohol deprivation effect and improves motor impulsive behavior in rats.Addiction biology · 2019Article
- Neuroimaging of reward mechanisms in Gambling disorder: an integrative review.Molecular psychiatry · 2019Review
- Effects of Citalopram on Cue-Induced Alcohol Craving and Thalamic D2/3 Dopamine Receptor Availability.The international journal of neuropsychopharmacology · 2019Article
- Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Differences in White Matter Microstructure and Connectivity in Nontreatment-Seeking Individuals with Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2018Article
- Differential Activation of the Left and Right Cerebral Hemispheres of Individuals Who Use or are Dependent on Drugs of Abuse.Journal of drug abuse · 2018Article
- Transcriptional profiling of the rat nucleus accumbens after modest or high alcohol exposure.PloS one · 2017Article
- Is there a relation between novelty seeking, striatal dopamine release and frontal cortical thickness?PloS one · 2017Article
- Testing the Relations Among Family Disorganization, Delay Discounting, and Adolescent Alcohol Use: A Genetically Informed Study.Alcoholism, clinical and experimental research · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
rationaleDopamine (DA) in the ventral striatum (VST) has long been implicated in addiction pathologies, yet its role in temporal decision-making is not well-understood.
objectivesTo determine if VST DA D2 receptor availability corresponds with greater impulsive choice in both nontreatment-seeking alcoholics (NTS) and social drinkers (SD).
methodsNTS subjects (n = 10) and SD (n = 13) received PET scans at baseline with the D2/D3 radioligand [(11)C]raclopride (RAC). Outside the scanner, subjects performed a delay discounting procedure with monetary rewards. RAC binding potential (BPND) was estimated voxelwise, and correlations were performed to test for relationships between VST BPND and delay discounting performance. Self-reported impulsivity was also tested for correlations with BPND.
resultsAcross all subjects, greater impulsive choice for $20 correlated with lower BPND in the right VST. NTS showed greater impulsive choice than SD and were more impulsive by self-report. Across all subjects, the capacity of larger rewards to reduce impulsive choice (the magnitude effect) correlated negatively (p = 0.028) with problematic alcohol use (AUDIT) scores. Self-reported impulsivity did not correlate with BPND in VST.
conclusionsPreference for immediate reinforcement may reflect greater endogenous striatal DA or lower D2 number, or both. Alcoholic status did not mediate significant effects on VST BPND, suggesting minimal effects from alcohol exposure. The apparent lack of BPND correlation with self-reported impulsivity highlights the need for objective behavioral assays in the study of the neurochemical substrates of behavior. Finally, our results suggest that the magnitude effect may be more sensitive to alcohol-induced problems than single discounting measures.
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