ArticleInternational urology and nephrology2015
Clinicopathological and outcome analysis of adult lupus nephritis patients in China.
Article in International urology and nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Pooled it
- Treatment for lupus nephritis: an overview of systematic reviews and meta-analyses.Rheumatology international · 2017Pooled it
- Kidney Biopsy and Prognosis in Lupus Nephritis: Histological Predictors of Renal Outcome-A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- A Pooled Analysis of Sex Differences in Lupus Nephritis.Kidney international reports · 2026Article
- Prediction model for renal outcomes in Latin American Mestizo patients with pure proliferative lupus nephritis.Lupus science & medicine · 2025Article
- Prevention of the Progression of lupus Nephritis in MRL/lpr Mice by Modulating miR-9-5p/Foxo1 Axis.Physiological research · 2025Article
- Prognostic Factors of the Progression of Chronic Kidney Disease and the Development of End-Stage Renal Disease in Patients with Lupus Nephritis: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Clinical characteristics, prognosis, and predictive modeling in class IV ± V lupus nephritis.Frontiers in immunology · 2025Article
- Associations of the Total Cholesterol/high-density Lipoprotein Cholesterol Ratio with Outcomes in Lupus Nephritis.International journal of medical sciences · 2025Article
- Sex differences in mortality among patients with lupus nephritis.European journal of medical research · 2024Article
- Treatment outcome and survival status among adult patients treated for lupus nephritis in selected tertiary hospitals of Ethiopia.Scientific reports · 2024Article
- Searching for a prognostic index in lupus nephritis.European journal of medical research · 2023Article
- Article
- Review
- Clinicopathological study of male and female patients with lupus nephritis: a retrospective study.International urology and nephrology · 2018Article
- Article
- Article
- Serum Cytokines Th1, Th2, and Th17 Expression Profiling in Active Lupus Nephritis-IV: From a Southern Chinese Han Population.Mediators of inflammation · 2016Article
- Clinical outcomes and predictors of fetal and maternal consequences of pregnancy in lupus nephritis patients.International urology and nephrology · 2015Article
- Evaluating Sex Differences in the Characteristics and Outcomes of Lupus Nephritis: A Systematic Review and Meta-Analysis.Glomerular diseasesReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to assess clinicopathological characteristics and outcomes of lupus nephritis adult patients in China.
methodsClinicopathological features, treatment strategies, responses and outcome of 681 adult patients with biopsy-proved lupus nephritis were retrospectively analyzed.
resultsSix hundred and eighty-one LN patients were included and followed up for 52.5 ± 14.1 months. Differences in age, disease duration, BP, proteinuria, serum albumin, creatinine, ANCA-positive ratio and SLEDAI scores were noticed between male and female patients, indicating severer disease in male patients. LN IV patients were much severer in systemic damage as well as immunological changes. During follow-up, 354 patients achieved CR, 107 patients achieved PR, 95 patients progressed to ESRD and 36 patients died. Prognosis and treatment response of patients with different histological types differ apparently. Renal outcome of patients with LN II and III was benign, while LN IV, V and VI was poor. Cyclophosphamide was effective in most patients. MMF and CNI could be used as salvage treatment. In multivariate analysis, BP, sCr, hypocomplementemia, severe proliferative lesion (LN IV or VI) and SLEDAI score were recognized as independent indicators of poor renal outcome. Infections, especially pulmonary fungus infection, thrombotic microangiopathy are the most common causes of death in LN patients.
conclusionsClinicopathological characteristics, treatment responses and long-term outcomes differ remarkably in LN patients with different gender and pathological subtypes. New indicators of poor renal outcome were identified. Infections and TTP were the most common causes of death in LN patients.
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