ArticlePloS one2015
The CRE1 cytokinin pathway is differentially recruited depending on Medicago truncatula root environments and negatively regulates resistance to a pathogen.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Evolutionary Repurposing of Cytokinin Signaling in Plant Development and Symbiosis.Plants (Basel, Switzerland) · 2026Review
- Impacts of gene duplication in the evolution of symbiotic root nodule symbiosis in legumes.Frontiers in plant science · 2026Article
- The cytokinin histidine kinase receptors regulate nodulation, shoot and root development inFrontiers in plant science · 2026Article
- Exogenous ABA combined with cytokinin enhances drought resistance inFrontiers in plant science · 2026Article
- Review
- Comparative Metabolome and Transcriptome Analyses Reveal Differential Enrichment of Metabolites with Age inPlants (Basel, Switzerland) · 2024Article
- RNA sequencing in Artemisia annua L explored the genetic and metabolic responses to hardly soluble aluminum phosphate treatment.Functional & integrative genomics · 2023Article
- Cytokinin Perception in Ancient Plants beyond Angiospermae.International journal of molecular sciences · 2021Article
- Review
- Gibberellins negatively regulate the development of Medicago truncatula root system.Scientific reports · 2019Article
- A Stimulatory Role for Cytokinin in the Arbuscular Mycorrhizal Symbiosis of Pea.Frontiers in plant science · 2019Article
- Cytokinin perception in potato: new features of canonical players.Journal of experimental botany · 2018Article
- The Art of Self-Control - Autoregulation of Plant-Microbe Symbioses.Frontiers in plant science · 2018Article
- Unraveling the Initial Plant Hormone Signaling, Metabolic Mechanisms and Plant Defense Triggering the Endomycorrhizal Symbiosis Behavior.Frontiers in plant science · 2018Review
- The Medicago truncatula GRAS protein RAD1 supports arbuscular mycorrhiza symbiosis and Phytophthora palmivora susceptibility.Journal of experimental botany · 2017Article
- Article
- Comparative Genome-Wide-Association Mapping Identifies Common Loci Controlling Root System Architecture and Resistance toFrontiers in plant science · 2017Article
- Article
- Article
- NIN Is Involved in the Regulation of Arbuscular Mycorrhizal Symbiosis.Frontiers in plant science · 2016Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinins are phytohormones that regulate many developmental and environmental responses. The Medicago truncatula cytokinin receptor MtCRE1 (Cytokinin Response 1) is required for the nitrogen-fixing symbiosis with rhizobia. As several cytokinin signaling genes are modulated in roots depending on different biotic and abiotic conditions, we assessed potential involvement of this pathway in various root environmental responses. Phenotyping of cre1 mutant roots infected by the Gigaspora margarita arbuscular mycorrhizal (AM) symbiotic fungus, the Aphanomyces euteiches root oomycete, or subjected to an abiotic stress (salt), were carried out. Detailed histological analysis and quantification of cre1 mycorrhized roots did not reveal any detrimental phenotype, suggesting that MtCRE1 does not belong to the ancestral common symbiotic pathway shared by rhizobial and AM symbioses. cre1 mutants formed an increased number of emerged lateral roots compared to wild-type plants, a phenotype which was also observed under non-stressed conditions. In response to A. euteiches, cre1 mutants showed reduced disease symptoms and an increased plant survival rate, correlated to an enhanced formation of lateral roots, a feature previously linked to Aphanomyces resistance. Overall, we showed that the cytokinin CRE1 pathway is not only required for symbiotic nodule organogenesis but also affects both root development and resistance to abiotic and biotic environmental stresses.
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