Evidence map›Paper›PMID 25562549›Full record

ReviewAllergy and asthma proceedings

Burden of chronic obstructive pulmonary disease: healthcare costs and beyond.

Sara M May, James T C Li

Registry-linked trialAbstract readReview
In one paragraph

Review in Allergy and asthma proceedings. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05947253 (Comparative Effects of BBT and Active Cycle of Breathing Technique on Dyspnea and Quality of Life in COPD), which is not on this map. Cited by 134 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05947253 naunknown statusnot on this map

Comparative Effects of BBT and Active Cycle of Breathing Technique on Dyspnea and Quality of Life in COPD

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2023Enrolled40ConditionsCOPDArmsBuyteko breathing technique, active cycle of breathing technique
3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Multi-Ancestry Mendelian Randomization Reveals Lipid-Associated Genetic Risk Factors for COPD.International journal of chronic obstructive pulmonary disease · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Identifying risk factors for COPD and adult-onset asthma: an umbrella review.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. The economic burden of chronic obstructive pulmonary disease (COPD) in Europe: results from a systematic review of the literature.The European journal of health economics : HEPAC : health economics in prevention and care · 2020
    Pooled it
  10. Trial
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Exacerbations and Healthcare Burden of COPD with Type 2 Inflammation: US Claims Analysis.International journal of chronic obstructive pulmonary disease · 2026
    Article
  20. Article

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sara M MayDivision of Allergic Diseases, Mayo Clinic, Rochester, MN, USA.
James T C Li

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
NCATS NIH HHS UL1 TR000135
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating respiratory condition that leads to significant burden, both medically and financially. It affects millions of people worldwide and causes significant morbidity and mortality. Most detailed information related to its prevalence, morbidity, and mortality comes from high-income countries, but 90% of COPD-related deaths occur in low- and middle-income countries. Cigarette smoking is the main risk factor for developing COPD, but other risk factors do exist and need to be recognized. A majority of morbidity and mortality as well as health care costs occur from acute exacerbations of COPD with a known phenotype of patients being "frequent exacerbators." Health care costs for COPD are not only from treatment of exacerbations, such as hospitalization, but also medication costs for maintenance therapy and outpatient treatment. COPD has been linked with many comorbidities leading to significant burden of disease. The goal of this review is to evaluate the overall burden of disease including prevalence, morbidity, mortality, health care costs, and economic costs.

Indexed as

Cost of IllnessDisease ProgressionHealth Care CostsHospitalizationHumansMorbidityMortalityPrevalencePulmonary Disease, Chronic ObstructiveRisk Factors

Identifiers

PMID25562549
PMCPMC5554331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.