ArticleClinical and experimental hypertension (New York, N.Y. : 1993)2015
Age-related hypertension and salt sensitivity are associated with unique cortico-medullary distribution of D1R, AT1R, and NADPH-oxidase in FBN rats.
Article in Clinical and experimental hypertension (New York, N.Y. : 1993), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Synergistic Effect of Uroguanylin and DJournal of the American Heart Association · 2022Article
- Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension.Antioxidants & redox signaling · 2021Review
- High salt-induced weakness of anti-oxidative function of natriuretic peptide receptor-C and podocyte damage in the kidneys of Dahl rats.Chinese medical journal · 2020Article
- Sodium-hydrogen exchanger regulatory factor-1 (NHERF1) confers salt sensitivity in both male and female models of hypertension in aging.Life sciences · 2020Article
- Kidney dopamine DAmerican journal of physiology. Renal physiology · 2019Article
- Mechanisms of altered renal sodium handling in age-related hypertension.American journal of physiology. Renal physiology · 2018Review
- Biomarkers for Chronic Kidney Disease Associated with High Salt Intake.International journal of molecular sciences · 2017Review
- Superoxide increases angiotensin II AT1 receptor function in human kidney-2 cells.FEBS open bio · 2016Article
- Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats.Oxidative medicine and cellular longevity · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
We examined effects of normal (NS) and high salt (HS) on blood pressure (BP) and cortico-medullary distribution of dopamine D1 receptor (D1R), angiotensin AT1 receptor (AT1R), NADPH oxidase-gp(91phox), and sodium transporters (NHE-3, Na, K ATPase) in adult and aged rats. Aged rats fed with NS diet had higher BP, which further increased with HS. HS increased D1R mRNA and protein levels in cortex and medulla of adult rats. NS or HS fed-aged rats had higher AT1R and gp(91phox) mRNA levels in cortex and medulla. Aged rats fed with NS diet had higher gp(91phox) protein levels in cortex. HS diet increased AT1R and gp(91phox) protein levels in medulla of aged rats. Aged rats fed with NS or HS diet had higher NHE-3 protein levels in medulla. HS increased Na, K ATPase protein levels in medulla of aged rats. HS increased urinary kidney injury molecule-1 (KIM-1) but not protein or albumin levels in aged rats. These results suggest that cortical gp(91phox) and medullary NHE-3 contribute to age-related hypertension. Whereas D1R (cortical and medullary) together with medullary AT1R, gp(91phox) and Na, K-ATPase contribute to salt sensitivity in aged rats. And, KIM-1 may be a better marker for kidney damage.
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