ArticleBritish journal of cancer2015
Childhood body mass index in relation to future risk of oesophageal adenocarcinoma.
Article in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Association of childhood and adolescence obesity with incidence and mortality of adulthood cancers. A systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Pooled it
- Body size and occupational physical activity during the life course and gastrointestinal cancers.American journal of epidemiology · 2025Article
- Article
- Is early-life obesity associated with kidney cancer in adulthood?-insights from genetic studies.Translational andrology and urology · 2025Article
- Not Only Metabolic Complications of Childhood Obesity.Nutrients · 2024Review
- Global burden and epidemiology of Barrett oesophagus and oesophageal cancer.Nature reviews. Gastroenterology & hepatology · 2021Review
- Epidemiology of Barrett's Esophagus and Esophageal Adenocarcinoma: Implications for Screening and Surveillance.Gastrointestinal endoscopy clinics of North America · 2021Review
- Birthweight, childhood overweight, height and growth and adult cancer risks: a review of studies using the Copenhagen School Health Records Register.International journal of obesity (2005) · 2020Review
- Prediagnostic adult body mass index change and esophageal adenocarcinoma survival.Cancer medicine · 2020Article
- Parental Perceptions and Behaviors Regarding Child Weight Status among Toddlers Born Preterm.American journal of perinatology · 2020Article
- Overweight Patterns Between Childhood and Early Adulthood and Esophageal and Gastric Cardia Adenocarcinoma Risk.Obesity (Silver Spring, Md.) · 2019Article
- Barrett's Esophagus and Esophageal Adenocarcinoma: How Common Are They Really?Digestive diseases and sciences · 2018Review
- Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age.Gastroenterology research and practice · 2018Article
- Body weight trajectories and risk of oesophageal and gastric cardia adenocarcinomas: a pooled analysis of NIH-AARP and PLCO Studies.British journal of cancer · 2017Article
- Early Life Exposures and Adult Cancer Risk.Epidemiologic reviews · 2017Review
- Body mass index and long-term risk of death from esophageal squamous cell carcinoma in a Chinese population.Thoracic cancer · 2016Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMiddle-aged obese adults are at substantially elevated risk of oesophageal adenocarcinoma. It is unclear whether this risk originates earlier in life.
methodsWe assessed associations between childhood body mass index (BMI) and height-measured annually between ages 7 and 13-with adult oesophageal adenocarcinoma in a cohort from the Copenhagen School Health Records Register. Analyses included 255 053 children born during 1930-1971. Danish Cancer Registry linkage provided outcomes. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression.
resultsDuring 5.4 million person-years of follow-up, 254 (216 males) incident oesophageal adenocarcinomas occurred. At each examined age, cancer risk increased linearly per unit BMI z-score, although associations were only statistically significant for ages 9-13. The HR for the age of 13 years was 1.31 (95% CI: 1.13, 1.51) per unit BMI z-score. Associations were similar in men and women and across birth cohorts. Childhood height was not related to cancer risk in men but was in women, although these analyses included just 38 female cases. HRs per unit height z-score at the age of 13 years were 1.04 (0.90, 1.19) in males and 1.77 (1.27, 2.47) in females, with similar results observed at the other examined ages.
conclusionIndividuals with higher childhood BMI were at elevated risk of oesophageal adenocarcinoma, even though these cancers occurred many decades later in life. Although the mechanisms require further investigation, our findings provide additional evidence for the long-term health risks of childhood obesity.
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