ArticlePLoS biology2015
Finding our way through phenotypes.
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In one paragraph
Article in PLoS biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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93citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Building phenotypic character matrices for phylogenetic inference: exploration of 35 years of practice.Biological reviews of the Cambridge Philosophical Society · 2026Pooled it
- Review
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- ODBAE: a high-performance model identifying complex phenotypes in high-dimensional biological datasets.Communications biology · 2025Article
- Wing spot in a tropical and a temperate drosophilid: C = C enrichment and conserved thermal response.BMC ecology and evolution · 2025Article
- The Value Proposition of Coordinated Population Cohorts Across Africa.Annual review of biomedical data science · 2024Review
- Roadmap for a European cancer data management and precision medicine infrastructure.Nature cancer · 2024Article
- GallOnt: An ontology for plant gall phenotypes.Biodiversity data journal · 2024Article
- Computable species descriptions and nanopublications: applying ontology-based technologies to dung beetles (Coleoptera, Scarabaeinae).Biodiversity data journal · 2024Article
- Comparing ant morphology measurements from microscope and online AntWeb.org 2D z-stacked images.Ecology and evolution · 2023Article
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- Assessing Bayesian Phylogenetic Information Content of Morphological Data Using Knowledge From Anatomy Ontologies.Systematic biology · 2022Article
- Prenatal phenotyping: A community effort to enhance the Human Phenotype Ontology.American journal of medical genetics. Part C, Seminars in medical genetics · 2022Article
- Association of Pathogenic Variants in Hereditary Cancer Genes With Multiple Diseases.JAMA oncology · 2022Article
- Past and future uses of text mining in ecology and evolution.Proceedings. Biological sciences · 2022Review
- Pleiotropy data resource as a primer for investigating co-morbidities/multi-morbidities and their role in disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Article
- The Agricultural Genome to Phenome Initiative (AG2PI): creating a shared vision across crop and livestock research communities.Genome biology · 2022Article
- The diversity, evolution, and development of setal morphologies in bumble bees (Hymenoptera: Apidae:PeerJ · 2022Article
- Formalizing Phenotypes of Regeneration.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Genome Fractionation and Loss of Heterozygosity in Hybrids and Polyploids: Mechanisms, Consequences for Selection, and Link to Gene Function.Molecular biology and evolution · 2021Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
74 authors.
Andrew R DeansDepartment of Entomology, Pennsylvania State University, University Park, Pennsylvania, United States of America.
Suzanna E LewisGenome Division, Lawrence Berkeley National Lab, Berkeley, California, United States of America.
Eva HualaDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California, United States of America; Phoenix Bioinformatics, Palo Alto, California, United States of America.
Salvatore S AnzaldoSchool of Life Sciences, Arizona State University, Tempe, Arizona, United States of America.
Michael AshburnerDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
James P BalhoffNational Evolutionary Synthesis Center, Durham, North Carolina, United States of America.
David C BlackburnDepartment of Vertebrate Zoology and Anthropology, California Academy of Sciences, San Francisco, California, United States of America.
Judith A BlakeThe Jackson Laboratory, Bar Harbor, Maine, United States of America.
J Gordon BurleighDepartment of Biology, University of Florida, Gainesville, Florida, United States of America.
Bruno ChanetMuséum national d'Histoire naturelle, Département Systématique et Evolution, Paris, France.
Laurel D CooperDepartment of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, United States of America.
Mélanie CourtotMolecular Biology and Biochemistry Department, Simon Fraser University, Burnaby, British Columbia, Canada.
Sándor CsöszMTA-ELTE-MTM, Ecology Research Group, Pázmány Péter sétány 1C, Budapest, Hungary.
Hong CuiSchool of Information Resources and Library Science, University of Arizona, Tucson, Arizona, United States of America.
Wasila DahdulDepartment of Biology, University of South Dakota, Vermillion, South Dakota, United States of America.
Sandip DasDepartment of Botany, University of Delhi, Delhi, India.
T Alexander DececchiDepartment of Biology, University of South Dakota, Vermillion, South Dakota, United States of America.
Agnes DettaiMuséum national d'Histoire naturelle, Département Systématique et Evolution, Paris, France.
Rui DiogoDepartment of Anatomy, Howard University College of Medicine, Washington D.C., United States of America.
Robert E DruzinskyDepartment of Oral Biology, College of Dentistry, University of Illinois, Chicago, Illinois, United States of America.
Michel DumontierStanford Center for Biomedical Informatics Research, Stanford, California, United States of America.
Nico M FranzSchool of Life Sciences, Arizona State University, Tempe, Arizona, United States of America.
Frank FriedrichBiocenter Grindel and Zoological Museum, Hamburg University, Hamburg, Germany.
George V GkoutosDepartment of Computer Science, Aberystwyth University, Aberystwyth, Ceredigion, United Kingdom.
Melissa HaendelDepartment of Medical Informatics & Epidemiology, Oregon Health & Science University, Portland, Oregon, United States of America.
Luke J HarmonDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, United States of America.
Terry F HayamizuMouse Genome Informatics, The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Yongqun HeUnit for Laboratory Animal Medicine, Department of Microbiology and Immunology, Center for Computational Medicine and Bioinformatics, and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Heather M HinesDepartment of Entomology, Pennsylvania State University, University Park, Pennsylvania, United States of America.
Nizar IbrahimDepartment of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, United States of America.
Laura M JacksonDepartment of Biology, University of South Dakota, Vermillion, South Dakota, United States of America.
Pankaj JaiswalDepartment of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, United States of America.
Christina James-ZornCincinnati Children's Hospital, Division of Developmental Biology, Cincinnati, Ohio, United States of America.
Sebastian KöhlerInstitute for Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Guillaume LecointreMuséum national d'Histoire naturelle, Département Systématique et Evolution, Paris, France.
Hilmar LappNational Evolutionary Synthesis Center, Durham, North Carolina, United States of America.
Carolyn J LawrenceDepartment of Genetics, Development and Cell Biology and Department of Agronomy, Iowa State University, Ames, Iowa, United States of America.
Nicolas Le NovèreSignalling ISP, Babraham Institute, Babraham, Cambridgeshire, UK.
John G LundbergDepartment of Ichthyology, The Academy of Natural Sciences, Philadelphia, Pennsylvania, United States of America.
James MacklinEastern Cereal and Oilseed Research Centre, Ottawa, Ontario, Canada.
Austin R MastDepartment of Biological Science, Florida State University, Tallahassee, Florida, United States of America.
Peter E MidfordRichmond, Virginia, United States of America.
István MikóDepartment of Entomology, Pennsylvania State University, University Park, Pennsylvania, United States of America.
Christopher J MungallGenome Division, Lawrence Berkeley National Lab, Berkeley, California, United States of America.
Anika OellrichEuropean Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.
David Osumi-SutherlandEuropean Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.
Helen ParkinsonEuropean Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.
Martín J RamírezDivision of Arachnology, Museo Argentino de Ciencias Naturales - CONICET, Buenos Aires, Argentina.
Stefan RichterAllgemeine & Spezielle Zoologie, Institut für Biowissenschaften, Universität Rostock, Universitätsplatz 2, Rostock, Germany.
Peter N RobinsonInstitut für Medizinische Genetik und Humangenetik Charité - Universitätsmedizin Berlin, Berlin, Germany.
Alan RuttenbergSchool of Dental Medicine, University at Buffalo, Buffalo, New York, United States of America.
Katja S SchulzSmithsonian Institution, National Museum of Natural History, Washington, D.C., United States of America.
Erik SegerdellKnight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America.
Katja C SeltmannDivision of Invertebrate Zoology, American Museum of Natural History, New York, New York, United States of America.
Michael J SharkeyDepartment of Entomology, University of Kentucky, Lexington, Kentucky, United States of America.
Aaron D SmithDepartment of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, United States of America.
Barry SmithDepartment of Philosophy, University at Buffalo, Buffalo, New York, United States of America.
Chelsea D SpechtDepartment of Plant and Microbial Biology, Integrative Biology, and the University and Jepson Herbaria, University of California, Berkeley, California, United States of America.
R Burke SquiresBioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Robert W ThackerDepartment of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Anne ThessenThe Data Detektiv, 1412 Stearns Hill Road, Waltham, Massachusetts, United States of America.
Jose Fernandez-TrianaCanadian National Collection of Insects, Ottawa, Ontario, Canada.
Mauno VihinenDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Peter D VizeDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Lars VogtUniversität Bonn, Institut für Evolutionsbiologie und Ökologie, Bonn, Germany.
Christine E WallDepartment of Evolutionary Anthropology, Duke University, Durham, North Carolina, United States of America.
Ramona L WallsiPlant Collaborative University of Arizona, Thomas J. Keating Bioresearch Building, Tucson, Arizona, United States of America.
Monte WesterfeldInstitute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America.
Robert A WhartonDepartment of Entomology, Texas A & M University, College, Station, Texas, United States of America.
Christian S WirknerAllgemeine & Spezielle Zoologie, Institut für Biowissenschaften, Universität Rostock, Universitätsplatz 2, Rostock, Germany.
James B WoolleyDepartment of Entomology, Texas A & M University, College, Station, Texas, United States of America.
Matthew J YoderIllinois Natural History Survey, University of Illinois, Champaign, Illinois, United States of America.
Aaron M ZornCincinnati Children's Hospital, Division of Developmental Biology, Cincinnati, Ohio, United States of America.
Paula MabeeDepartment of Biology, University of South Dakota, Vermillion, South Dakota, United States of America.
Funding
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9MMouse Genome DatabaseU41HG000330 · NHGRI · JACKSON LABORATORY · PI BLAKE, JUDITH A, BULT, CAROL J · 2011 to 2020
$45.5MXenbase: the Xenopus Model Organism KnowledgebaseP41HD064556 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI PETER D VIZE, Aaron M Zorn · 2010 to 2026
$24.9MBiotechnology and Biological Sciences Research Council BBS/E/B/000C0419NCI NIH HHS P30 CA034196NHGRI NIH HHS U41 HG000330NICHD NIH HHS P41 HD064556
Abstract
Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility.
Indexed as
Genetic Association StudiesAnimalsComputational BiologyDatabases, FactualData CurationGene-Environment InteractionGenomicsHumansPhenotypeReference StandardsReproducibility of ResultsTerminology as Topic
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