ArticleAnnals of the American Thoracic Society2015
Diagnosing lung carcinomas with optical coherence tomography.
Article in Annals of the American Thoracic Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- The clinical usefulness of optical coherence tomography during cancer interventions.Journal of cancer research and clinical oncology · 2018Pooled it
- Segmental airway adenocarcinoma-simulating phantom for endoscopic near-infrared optical coherence tomography.Journal of biomedical optics · 2025Article
- OCT in Oncology and Precision Medicine: From Nanoparticles to Advanced Technologies and AI.Bioengineering (Basel, Switzerland) · 2025Review
- Mechanisms on How Matricellular Microenvironments Sustain Idiopathic Pulmonary Fibrosis.International journal of molecular sciences · 2025Review
- Spatial lung imaging in clinical and translational settings.Breathe (Sheffield, England) · 2024Review
- Motor-free telerobotic endomicroscopy for steerable and programmable imaging in complex curved and localized areas.Nature communications · 2024Article
- Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation.Pathology oncology research : POR · 2023Article
- Quantification and visualization of metastatic lung tumors in mice.Toxicological research · 2022Article
- Novel image features of optical coherence tomography for pathological classification of lung cancer: Results from a prospective clinical trial.Frontiers in oncology · 2022Article
- Optical coherence tomography.Nature reviews. Methods primers · 2022Article
- Endobronchial Optical Coherence Tomography for the Diagnosis of Fibrotic Interstitial Lung Disease: A Light at the End of the Tunnel?American journal of respiratory and critical care medicine · 2021Article
- Small airway dilation measured by endoscopic optical coherence tomography correlates with chronic lung allograft dysfunction.Journal of biomedical optics · 2021Article
- Reflection-mode virtual histology using photoacoustic remote sensing microscopy.Scientific reports · 2020Article
- Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement.Journal of biomedical optics · 2020Article
- Real-time colorectal cancer diagnosis using PR-OCT with deep learning.Theranostics · 2020Article
- Ten Years of Gabor-Domain Optical Coherence Microscopy.Applied sciences (Basel, Switzerland) · 2019Article
- Article
- New insights into spectral histopathology: infrared-based scoring of tumour aggressiveness of squamous cell lung carcinomas.Chemical science · 2019Article
- Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy.Journal of bronchology & interventional pulmonology · 2018Article
- Review of optical coherence tomography in oncology.Journal of biomedical optics · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleLung carcinoma diagnosis on tissue biopsy can be challenging because of insufficient tumor and lack of architectural information. Optical coherence tomography (OCT) is a high-resolution imaging modality that visualizes tissue microarchitecture in volumes orders of magnitude larger than biopsy. It has been proposed that OCT could potentially replace tissue biopsy.
objectivesWe aim to determine whether OCT could replace histology in diagnosing lung carcinomas. We develop and validate OCT interpretation criteria for common primary lung carcinomas: adenocarcinoma, squamous cell carcinoma (SCC), and poorly differentiated carcinoma.
methodsA total of 82 ex vivo tumor samples were included in a blinded assessment with 3 independent readers. Readers were trained on the OCT criteria, and applied these criteria to diagnose adenocarcinoma, SCC, or poorly differentiated carcinoma in an OCT validation dataset. After a 7-month period, the readers repeated the training and validation dataset interpretation. An independent pathologist reviewed corresponding histology. MEASUREMENTS AND MAIN
resultsThe average accuracy achieved by the readers was 82.6% (range, 73.7-94.7%). The sensitivity and specificity for adenocarcinoma were 80.3% (65.7-91.4%) and 88.6% (80.5-97.6%), respectively. The sensitivity and specificity for SCC were 83.3% (70.0-100.0%) and 87.0% (75.0-96.5%), respectively. The sensitivity and specificity for poorly differentiated carcinoma were 85.7% (81.0-95.2%) and 97.6% (92.9-100.0%), respectively.
conclusionsAlthough these results are encouraging, they indicate that OCT cannot replace histology in the diagnosis of lung carcinomas. However, OCT has potential to aid in diagnosing lung carcinomas as a complement to tissue biopsy, particularly when insufficient tissue is available for pathology assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.