Absence of Association between -1131T>C Polymorphism in the Apolipoprotein APOA5 Gene and Pediatric Metabolic Syndrome.

Sayedeh Ghazaleh Fatemi, Modjtaba Emadi-Baygi, Parvaneh Nikpour, Roya Kelishadi, Mahin Hashemipour

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Article in Iranian journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

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1citing papers in PubMed, 1 pooled it

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa.Bioscience reports · 2020
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sayedeh Ghazaleh FatemiDepartment of Genetics, School of Basic Sciences.

Modjtaba Emadi-BaygiDepartment of Genetics, School of Basic Sciences ; Research Institute of Biotechnology, School of Basic Sciences, Shahrekord University, Shahrekord.

Parvaneh NikpourPediatric Inherited Diseases Research Center, Isfahan University of Medical Sciences, Isfahan ; Department of Genetics and Molecular Biology, School of Medicine ; Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Roya KelishadiChild Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Mahin HashemipourChild Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn the present study, we evaluated the association of rs662799 variant of the APOA5 gene with Metabolic syndrome (MetS) in a sample of children and adolescents from Isfahan.

methodsThis case control study comprised 50 cases of MetS and 50 controls. Mismatched polymerase chain reaction-restriction fragment length polymorphism (mPCR-RFLP) was used to genotype -1131T>C polymorphism. Findings : No significant association was documented for APOA5 genotypes with the measured laboratory parameters for CC, CT, and TT genotypes in the two groups studied. By logistic regression using a dominant model, the odds ratio (95% confidence interval0 for the MetS was 0.38 (0.139-1.0350 and 0.29 (0.08-1.071 for the unadjusted and adjusted models, respectively.

conclusionThis study suggests that among studied children and adolescents, -1131T>C polymorphism in the APOA5 gene may not be a major contributor to the MetS risk.

Indexed as

Apolipoprotein A5 Gene; Metabolic Syndrome; Children; Adolescents; Triglyceride; Cholesterol

Identifiers

PMID25562027

PMCPMC4276588

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.