ArticleIranian journal of pharmaceutical research : IJPR2015
Evaluation of Anti-inflammatory and Analgesic Activity of the Extract and Fractions of Astragalus hamosus in Animal Models.
Article in Iranian journal of pharmaceutical research : IJPR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
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- Antinociceptive and anti-ulcerogenic effect of hydroethanolic stem bark extract of Ricinodendron heudelotii (Baill.) Pierre ex. Heckel (Euphorbiaceae): Involvement of the opioidergic pathway and attenuation of oxidative stress.Journal of traditional and complementary medicine · 2025Article
- Curcumin ZnO and MgO Nanoparticles Confer Protective Effects Against Ketamine-Induced Bipolar Disorder in Mice: Role of Brain-Derived Neurotrophic Factor.Advanced biomedical research · 2025Article
- Screening of Antiglaucoma, Antidiabetic, Anti-Alzheimer, and Antioxidant Activities ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Analgesic and Anti-Inflammatory Activities of 80% Methanol Extract and Solvent Fractions ofJournal of experimental pharmacology · 2023Article
- Screening forMolecules (Basel, Switzerland) · 2022Article
- Total phenolic, flavonoid contents, and biological activities of stem extracts ofSaudi journal of biological sciences · 2022Article
- Fabrication and Characterization of a Three-Dimensional Fibrin Gel Model to Evaluate Anti-Proliferative Effects of Astragalus hamosus Plant Extract on Breast Cancer Cells.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Potential Regulation of NF-κB by Curcumin in Coronavirus-Induced Cytokine Storm and Lung Injury.International journal of preventive medicine · 2022Review
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- CNS anti-depressant, anxiolytic and analgesic effects ofBiochemistry and biophysics reports · 2021Article
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- Antioxidant, Anti-Inflammatory, and Analgesic Activities of Aqueous Extract ofTheScientificWorldJournal · 2020Article
- Acute Oral Toxicity and Anti-inflammatory and Analgesic Effects of Aqueous and Methanolic Stem Bark Extracts ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- The effect of maternal forced exercise on offspring pain perception, motor activity and anxiety disorder: the role of 5-HT2 and D2 receptors andJournal of exercise rehabilitation · 2017Article
- The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway.Neurochemical research · 2017Article
- Anti-inflammatory and analgesic activities of solvent fractions of the leaves of Moringa stenopetala Bak. (Moringaceae) in mice models.BMC complementary and alternative medicine · 2017Article
- Preventive Effect of Maternal Forced Exercise on Offspring Pain Perception and Intensity: The Role of 5-HTAdvanced biomedical research · 2017Article
- Scientific investigation of crude alkaloids from medicinal plants for the management of pain.BMC complementary and alternative medicine · 2016Article
- Chitosan/Alginate-LoadedReproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to evaluate the anti-inflammatory and analgesic activities of the hydro-alcoholic extract of the pods of Astragalus hamosus (HAAH), a plant used in Iranian traditional medicine, and antinociceptive effects of different fractions in animal models. The anti-inflammatory effect was evaluated by the rat paw edema induced by formalin. Also the analgesic effect was examined by the acetic-acid-induced writhing response and hot plate test. The analgesic effects of chloroform, hexane, ethyl acetate and aqueous fractions were evaluated by the hot-plate method. The hydroalcoholic extract of Astragalus hamosus could reduce the edema in a dose-dependent manner (P<0.05). In the acute phase, the result of 1000 mg/Kg and in the chronic phase, the result of 100 and 300 mg/Kg of the extract were more significant and comparable with the effect of sodium salicylate. Also application of different doses of HAAH had significant anti-nociceptive effects on both animal models. The findings showed that HAAH at doses of 700 and 1000 mg/Kg produced analgesic effects comparable to sodium salicylate. The hexane and ethyl acetate (but not the other fractions) showed significant analgesic activity in hot plate test, when compared to morphine. The results of this study demonstrated the anti-inflammatory and analgesic effects of HAAH extract and hexane and ethyl acetate fractions of the extract in animal models and justify traditional use of this plant in the treatment of pain and inflammatory conditions. More studies to clarify the active components are necessary.
Indexed as
Identifiers
25561932PMC4277639W2124619533What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.