SynthesisWorld journal of gastroenterology2014
Reduced incidence and mortality from colorectal cancer with flexible-sigmoidoscopy screening: a meta-analysis.
Synthesis in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Is flexible sigmoidoscopy screening associated with reducing colorectal cancer incidence and mortality? a meta-analysis and systematic review.Frontiers in oncology · 2023Pooled it
- Systematic review of colorectal cancer screening guidelines for average-risk adults: Summarizing the current global recommendations.World journal of gastroenterology · 2018Pooled it
- Colorectal Cancer: Cost-effectiveness of Colonoscopy versus CT Colonography Screening with Participation Rates and Costs.Radiology · 2018Trial
- Innovative approaches in colorectal cancer screening: advances in detection methods and the role of artificial intelligence.Therapeutic advances in gastroenterology · 2025Review
- Article
- Review
- Effects of sigmoidoscopy screening (including colonoscopy) on colorectal cancer: APreventive medicine reports · 2024Article
- Feasibility and acceptability of motivational interviewing to promote colorectal cancer screening among average risk Chinese older adults.Asia-Pacific journal of oncology nursing · 2023Article
- Efficacy of the population-based pilot colorectal cancer screening, Csongrád county, Hungary, 2015Turkish journal of medical sciences · 2020Article
- Integrin α1 promotes tumorigenicity and progressive capacity of colorectal cancer.International journal of biological sciences · 2020Article
- Association of Race and Socioeconomic Status With Colorectal Cancer Screening, Colorectal Cancer Risk, and Mortality in Southern US Adults.JAMA network open · 2019Article
- A novel panel of stool-based DNA biomarkers for early screening of colorectal neoplasms in a Chinese population.Journal of cancer research and clinical oncology · 2019Article
- Using serum placenta growth factor could improve the sensitivity of colorectal cancer screening in fecal occult blood negative population: A multicenter with independent cohort validation study.Cancer medicine · 2019Article
- MicroRNA-128 targeting RPN2 inhibits cell proliferation and migration through the Akt-p53-cyclin pathway in colorectal cancer cells.Oncology letters · 2018Article
- Study ofJournal of gastrointestinal oncology · 2018Article
- [Multiple risk factors prediction models for high risk population of colorectal cancer].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Article
- Factors associated with the efficacy of polyp detection during routine flexible sigmoidoscopy.Frontline gastroenterology · 2018Article
- Diagnostic Value of MethylatedFrontiers in oncology · 2018Article
- Blood-Based Protein Signatures for Early Detection of Colorectal Cancer: A Systematic Review.Clinical and translational gastroenterology · 2017Article
- CMOST: an open-source framework for the microsimulation of colorectal cancer screening strategies.BMC medical informatics and decision making · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo conduct a systematic review and meta-analysis of published population-based randomized controlled trials (RCTs).
methodsRCTs evaluating the difference in mortality and incidence of colorectal cancer (CRC) between a screening flexible sigmoidoscopy (FS) group and control group (not assigned to screening FS) with a minimum 5 years median follow-up were identified by a search of MEDLINE and EMBASE databases and the Cochrane Central Register for Controlled Trials through August 2013. Random effects model was used for meta-analysis.
resultsFour RCTs with a total of 165659 patients in the FS group and 249707 patients in the control group were included in meta-analysis. Intention-to-treat analysis showed that there was a 22% risk reduction in total incidence of CRC (RR = 0.78, 95%CI: 0.74-0.83), 31% in distal CRC incidence (RR = 0.69, 95%CI: 0.63-0.75), and 9% in proximal CRC incidence (RR = 0.91, 95%CI: 0.83-0.99). Those who underwent screening FS were 18% less likely to be diagnosed with advanced CRC (OR = 0.82, 95%CI: 0.71-0.94). There was a 28% risk reduction in overall CRC mortality (RR = 0.72, 95%CI: 0.65-0.80) and 43% in distal CRC mortality (RR = 0.57, 95%CI: 0.45-0.72).
conclusionThis meta-analysis suggests that screening FS can reduce the incidence of proximal and distal CRC and mortality from distal CRC along with reduction in diagnosis of advanced CRC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.