Evidence map›Paper›PMID 25561721›Full record

ReviewCold Spring Harbor perspectives in medicine2015

Natural and sun-induced aging of human skin.

Laure Rittié, Gary J Fisher

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 279 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
279citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

279 citing papers in PubMed, 1 synthesis or guideline pooled it, 543 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  9. Article
  10. Synergistic Effects of Solar Exposure and Skin Sensitivity on Skin Aging: A Clinical Study Using Multimodal Noninvasive Measurements.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Observational
  11. Article
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  14. Review
  15. Microorganisms · 2026
    Review
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  18. Review
  19. Article
  20. Article

219 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Laure RittiéDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109.
Gary J FisherDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109.
University of Michigan–Ann Arbor · US

Funding

Transforming Growth Factor-Beta (TGF-b) Signaling in Photoaged and ChronologicallR01AG019364 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FISHER, GARY J, QUAN, TAIHAO · 2002 to 2014
$3.0M
Regulation of Extracellular Matrix Homeostatsis in Skin AgingR01AG031452 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FISHER, GARY J · 2009 to 2013
$1.5M
Mechanisms of Altered Skin Re-Epithelialization in AgingK01AR059678 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RITTIE, LAURE · 2010 to 2013
$385k
NIAMS NIH HHS AR059678NIAMS NIH HHS K01 AR059678NIA NIH HHS AG019364NIA NIH HHS AG031452NIA NIH HHS R01 AG019364NIA NIH HHS R01 AG031452
6 · The paper itself

Abstract

With worldwide expansion of the aging population, research on age-related pathologies is receiving growing interest. In this review, we discuss current knowledge regarding the decline of skin structure and function induced by the passage of time (chronological aging) and chronic exposure to solar UV irradiation (photoaging). Nearly every aspect of skin biology is affected by aging. The self-renewing capability of the epidermis, which provides vital barrier function, is diminished with age. Vital thermoregulation function of eccrine sweat glands is also altered with age. The dermal collagenous extracellular matrix, which comprises the bulk of skin and confers strength and resiliency, undergoes gradual fragmentation, which deleteriously impacts skin mechanical properties and dermal cell functions. Aging also affects wound repair, pigmentation, innervation, immunity, vasculature, and subcutaneous fat homeostasis. Altogether, age-related alterations of skin lead to age-related skin fragility and diseases.

Indexed as

Body Temperature RegulationCollagenExtracellular MatrixHumansRegenerationSkinSkin AgingSkin PigmentationSubcutaneous FatSunlightUltraviolet RaysCollagen

Identifiers

PMID25561721
PMCPMC4292080
OpenAlexW2101089137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.