ArticleEndocrine2015
Disease control and treatment modalities have impact on quality of life in acromegaly evaluated by Acromegaly Quality of Life (AcroQoL) Questionnaire.
Article in Endocrine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Questionnaire and tools: clinical powerful instrument in acromegaly diagnosis and management.Journal of endocrinological investigation · 2022Pooled it
- Disease-related burden and treatment experience in patients with acromegaly: a gender perspective.Journal of endocrinological investigation · 2026Article
- Personalized Medicine in Acromegaly: The ACROFAST Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Novel approach to bone comorbidity in resistant acromegaly.Pituitary · 2024Review
- High mortality risk among women with acromegaly still persists.Frontiers in endocrinology · 2024Observational
- Patient-reported outcomes in refractory hormone-producing pituitary adenomas: an unmet need.Pituitary · 2023Review
- Adherence to Acromegaly Treatment and Analysis of the Related Factors-A Real-World Study in Bulgaria.Pharmaceutics · 2023Article
- Sex difference in patients with controlled acromegaly-A multicentre survey.Clinical endocrinology · 2023Article
- Associations between paraclinical parameters, symptoms and quality of life in patients with acromegaly: a cross sectional study.Journal of patient-reported outcomes · 2022Article
- Differences in quality of life between genders in acromegaly.Endocrinology, diabetes & metabolism · 2021Observational
- Effects of growth hormone receptor antagonism and somatostatin analog administration on quality of life in acromegaly.Clinical endocrinology · 2021Article
- Current perspectives on the impact of clinical disease and biochemical control on comorbidities and quality of life in acromegaly.Reviews in endocrine & metabolic disorders · 2019Review
- Importance of Illness Acceptance Among Other Factors Affecting Quality of Life in Acromegaly.Frontiers in endocrinology · 2019Article
- Cognitive-behavioral therapy improves the quality of life of patients with acromegaly.Pituitary · 2018Review
- Personality Traits and Physical Complaints in Patients With Acromegaly: A Cross Sectional Multi-Center Study With Analysis of Influencing Factors.Frontiers in endocrinology · 2018Article
- Increased Risk of Persistent Glucose Disorders After Control of Acromegaly.Journal of the Endocrine Society · 2017Article
- Development of ACRODATPituitary · 2017Article
- Predictors of Quality of Life in Acromegaly: No Consensus on Biochemical Parameters.Frontiers in endocrinology · 2017Review
- Quality of Life in Patients with Acromegaly - A Romanian Single Center Cross-Sectional Study.Acta endocrinologica (Bucharest, Romania : 2005)Article
- ARE THERE RELIABLE PREDICTORS FOR THE IMPAIRED QUALITY OF LIFE IN PATIENTS WITH CUSHING'S SYNDROME?Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various factors influence quality of life (QoL) in acromegaly. Whether disease control and treatment approach are related to QoL is still a matter of debate. The aim of the present study was to evaluate QoL in patients with acromegaly using the disease-specific Acromegaly Quality of Life Questionnaire in respect to disease activity, treatment modalities, and other factors. We studied 212 patients with acromegaly in a cross-sectional manner over a 6-year period in a single tertiary center. As a second step, seventy of the patients who were with active disease at baseline were followed up prospectively and 45 of them were in remission at re-evaluation. In regard to the cross-sectional group, active acromegaly independently predicted worse appearance scores. Prior radiotherapy and older age were independent negative predictors of all scales. Female gender negatively predicted all scales except the appearance domain. Longer duration of remission predicted worse personal relations scores in biochemically controlled patients. The use of somatostatin analog (SSA) was associated with worse personal relations scores, while higher IGF-1 index predicted worse appearance scores in patients with active acromegaly. In the prospective group, achievement of remission independently predicted improvement of the total scale. Lower corresponding baseline scores predicted improvement of the total, physical, and appearance scales, while the absence of hypopituitarism independently predicted improvement of the appearance scale. The use of SSA was associated with improvement of the total and appearance scores. In conclusion, QoL is a multifactorial issue that needs an individualized approach for detection and management.
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