ArticleInternational journal of molecular sciences2014
Identification of retinopathy of prematurity related miRNAs in hyperoxia-induced neonatal rats by deep sequencing.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Retinopathy of Prematurity and MicroRNAs.Biomedicines · 2025Review
- Transcription Factor EGR1 Facilitates Neovascularization in Mice with Retinopathy of Prematurity by Regulating the miR-182-5p/EFNA5 Axis.Biochemical genetics · 2024Article
- Novel Potential Biomarkers for Retinopathy of Prematurity.Frontiers in medicine · 2022Review
- MicroRNAs in Vascular Eye Diseases.International journal of molecular sciences · 2020Review
- Circular RNA expression profiles in neonatal rats following hypoxic-ischemic brain damage.International journal of molecular medicine · 2019Article
- MicroRNA expression profile in retina and choroid in oxygen-induced retinopathy model.PloS one · 2019Article
- Evaluation of the plasma microRNA levels in stage 3 premature retinopathy with plus disease: preliminary study.Eye (London, England) · 2018Article
- Differentially expressed miRNAs in premature infants with retinopathy-a bioinformatics analysis.International journal of ophthalmology · 2018Article
- Gene Expression Analysis of the Effect of Ischemic Infarction in Whole Blood.International journal of molecular sciences · 2017Article
- Retinal expression of small non-coding RNAs in a murine model of proliferative retinopathy.Scientific reports · 2016Article
- Biomarkers for Bronchopulmonary Dysplasia in the Preterm Infant.Frontiers in pediatrics · 2016Review
- Single and Compound Knock-outs of MicroRNA (miRNA)-155 and Its Angiogenic Gene Target CCN1 in Mice Alter Vascular and Neovascular Growth in the Retina via Resident Microglia.The Journal of biological chemistry · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinopathy of prematurity (ROP) remains a major problem for many preterm infants. MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression at the posttranscriptional level and have been studied in many diseases. To understand the roles of miRNAs in ROP model rats, we constructed two small RNA libraries from the plasma of hyperoxia-induced rats and normal controls. Sequencing data revealed that 44 down-regulated microRNAs and 22 up-regulated microRNAs from the hyperoxia-induced rats were identified by deep sequencing technology. Some of the differentially expressed miRNAs were confirmed by quantitative reverse transcription-PCR (qRT-PCR). A total of 594 target genes of the differentially expressed microRNAs were identified using a bioinformatics approach. Functional annotation analysis indicated that a number of pathways might be involved in angiogenesis, cell proliferation and cell differentiation, which might be involved in the genesis and development of ROP. The elevated expression level of the vascular endothelial growth factor (VEGF) protein in the hyperoxia-induced neonatal rats was also confirmed by enzyme linked immunosorbent assay (ELISA). This study provides some insights into the molecular mechanisms that underlie ROP development, thereby aiding the diagnosis and treatment of this disease.
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