ReviewGenes, brain, and behavior2015
Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions.
Review in Genes, brain, and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
100 citing papers in PubMed, 163 citations in OpenAlex.
- Sex-biased computations underlying differential set shift performance in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A Single Dose of a Psychedelic Drug Repairs Prefrontal Cortex Synaptic Physiology in a Mouse Model of Prenatal Alcohol Exposure.Brain and behavior · 2026Article
- Sensory integration, temporal prediction, and rule discovery reflect interdependent inference processes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Microglia Promote Neurodegeneration and Hyperkatifeia during Withdrawal and Abstinence from Binge Alcohol.The American journal of pathology · 2026Article
- Reward contingency reorganizes lateral orbitofrontal cortex pyramidal neuron activity from reward-aligned to action-aligned during associative learning.Frontiers in cellular neuroscience · 2026Article
- Layer-specific cortical dynamics during transitions from error monitoring to decision execution in reversal learning.Communications biology · 2025Article
- Cholinergic interneurons of the dorsomedial striatum mediate winner-loser effects on social hierarchy dynamics in male mice.iScience · 2025Article
- Cognitive flexibility of male rats is increased by augmented punishment in a reversal learning task but ketamine has no detectable long-term effects.Psychopharmacology · 2025Article
- Microglia promote neurodegeneration and hyperkatifeia during withdrawal and prolonged abstinence from binge alcohol.bioRxiv : the preprint server for biology · 2025Article
- Human CLOCK enhances neocortical function.Nature neuroscience · 2025Article
- Single-dose psychedelic enhances cognitive flexibility and reversal learning in mice weeks after administration.Psychedelics · 2025Article
- Neurostimulation to Improve Cognitive Flexibility.Current opinion in behavioral sciences · 2025Article
- Orexinergic modulation of chronic jet lag-induced deficits in mouse cognitive flexibility.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- An Open-Source 3D-Printable Platform for Testing Head-Fixed Cognitive Flexibility in Rodents.eNeuro · 2025Article
- Psychedelic enhancement of flexible learning weeks after a single dose.bioRxiv : the preprint server for biology · 2024Article
- Assessing the Benefit of Dietary Choline Supplementation Throughout Adulthood in the Ts65Dn Mouse Model of Down Syndrome.Nutrients · 2024Article
- Article
- Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility.Translational psychiatry · 2024Article
- Ketamine produces no detectable long-term positive or negative effects on cognitive flexibility or reinforcement learning of male rats.Psychopharmacology · 2024Article
- Optogenetic stimulation of corticostriatal circuits improves behavioral flexibility in mice with prenatal alcohol exposure.Neuropharmacology · 2024Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Research examining the contribution of genetics to behavior is increasingly focused on higher order behavioral and cognitive processes including the ability to modify behaviors when environmental demands change. The frontal cortices of mammals, including rodents, subserve a diverse set of behavioral and cognitive functions including motor planning, social behavior, evaluation of expected outcomes and working memory, which may be particularly sensitive to genetic factors and interactions with experience (e.g. stress). Behavioral flexibility is a core attribute of these functions. This review orients readers to the current landscape of the literature on the frontocortical bases of behavioral flexibility in rodent laboratory experiments. Studies are divided into three broad categories: reversal learning, inhibitory learning and set-shifting. Functional dissociations within the broader scope of behavioral flexibility are reviewed, followed by discussion of the associations between specific components of frontal cortex and specific aspects of relevant behavioral processes. Finally, the authors identify open questions that need to be addressed to better establish the constituents of frontal cortex underlying behavioral flexibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.