ArticleInflammopharmacology2015
Modulation of PPARγ and TNFα by emu oil and glycyrrhizin in ulcerative colitis.
Article in Inflammopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Effects of glycyrrhizin on healing and prevention of recurrent aphthous stomatitis in hamster models.PloS one · 2026Article
- Unveiling phytoconstituents and the anti-inflammatory potential of Crassula tetragona L. in ulcerative colitis: A focus on the PPARγ/SIRT1 axis.Inflammopharmacology · 2026Article
- Maslinic Acid Ameliorates DSS-Induced Experimental Colitis by Suppressing Th Cell-Mediated Inflammation via AICD Induction.Phytotherapy research : PTR · 2025Article
- Harnessing nature's pharmacy: investigating natural compounds as novel therapeutics for ulcerative colitis.Frontiers in pharmacology · 2024Review
- Terpenes: Modulating anti-inflammatory signaling in inflammatory bowel disease.Pharmacology & therapeutics · 2023Review
- Glycosides as Potential Medicinal Components for Ulcerative Colitis: A Review.Molecules (Basel, Switzerland) · 2023Review
- Review
- The Anti-Inflammatory Properties of Licorice (International journal of molecular sciences · 2022Review
- Colitis Is Effectively Ameliorated by (±)-8-Acetonyl-dihydrocoptisine via the XBP1-NF-κB Pathway.Frontiers in pharmacology · 2017Article
- Emu Oil: A Potential Adjunct to Inflammatory Bowel Disease Treatment?Inflammatory intestinal diseasesReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ulcerative Colitis (UC) is an inflammatory bowel disorder that affects colon and rectum. Treatments in many UC patients remain variably effective and are associated with considerable adverse effects. So the present study was undertaken to explore the antiinflammatory effects of emu oil, glycyrrhizin, and combination of emu oil and glycyrrhizin in acetic acid-induced UC in rats. UC was induced by intracolonic instillation of 5% acetic acid in rats. Emu oil and glycyrrhizin were orally administered to test groups. Severity of colitis was scored macroscopically and microscopically. The levels of myeloperoxidase and antioxidant enzymes namely catalase, superoxide dismutase and glutathione peroxidase were assessed spectrophotometrically. Expressions of PPARγ and TNFα were studied by real-time PCR. Acetic acid caused severe damage to colon and rectum. Emu oil and glycyrrhizin were found to significantly reduce macroscopic and microscopic lesions and decrease levels of myeloperoxidase. There was a significant improvement of antioxidant levels in treatment groups compared to acetic acid group. Combination of emu oil and glycyrrhizin showed a markedly greater modulation of PPARγ and TNFα expression than emu oil and glycyrrhizin when administered alone. Combination of emu oil and glycyrrhizin might have had synergistic effects in regulating PPARγ and TNFα. Further studies on mechanism of action of emu oil and glycyrrhizin combination would pave the way to define possibility of this combination as effective in the management of UC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.