Evidence map›Paper›PMID 25560974›Full record

ArticleCancer epidemiology2015

Racial differences in three major NHL subtypes: descriptive epidemiology.

Yang Li, Yu Wang, Zhuoyue Wang, Danhui Yi, Shuangge Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  5. Total costs of different lines of treatment in diffuse large B-cell lymphoma in Denmark - a real-world data analysis.The European journal of health economics : HEPAC : health economics in prevention and care · 2026
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yang Li *School of Statistics and The Center for Applied Statistics, Renmin University of China, 59 Zhongguancun Ave. Beijing, 100872, China.
Yu Wang *School of Statistics and The Center for Applied Statistics, Renmin University of China, 59 Zhongguancun Ave. Beijing, 100872, China.
Zhuoyue Wang *School of Statistics and The Center for Applied Statistics, Renmin University of China, 59 Zhongguancun Ave. Beijing, 100872, China.
Danhui YiSchool of Statistics and The Center for Applied Statistics, Renmin University of China, 59 Zhongguancun Ave. Beijing, 100872, China.
Shuangge MaSchool of Statistics and The Center for Applied Statistics, Renmin University of China, 59 Zhongguancun Ave. Beijing, 100872, China.

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
NCATS NIH HHS UL1 TR000142NCI NIH HHS P30 CA016359NCI NIH HHS P30 CA16359
6 · The paper itself

Abstract

backgroundNHL (non-Hodgkin lymphoma) consists of over 60 subtypes, ranging from slow-growing to very aggressive. The three largest subtypes are DLBCL (diffuse large B-cell lymphoma), FL (follicular lymphoma), and CLL/SLL (chronic lymphocytic leukemia/small lymphocytic lymphoma). For each subtype, different racial groups have different presentations, etiologies, and prognosis patterns.

methodsSEER (Surveillance, Epidemiology, and End Results) data on DLBCL, FL, and CLL/SLL patients diagnosed between 1992 and 2010 were analyzed. Racial groups studied included NHW (non-Hispanic whites), HW (Hispanic whites), blacks, and API (Asians and Pacific Islanders). Patient characteristics, age-adjusted incidence rate, and survival were compared across races. Stratification and multivariate analysis were conducted.

resultsThere are significant racial differences for patients' characteristics, including gender, age at diagnosis, stage, lymph site, and age, and the patterns vary across subtypes. NHWs have the highest incidence rates for all three subtypes, followed by HWs (DLBCL and FL) and blacks (CLL/SLL). The dependence of the incidence rate on age and gender varies across subtypes. For all three subtypes, NHWs have the highest five-year relative survival rates, followed by HWs. When stratified by stage, racial difference is significant in multiple multivariate Cox regression analyses.

conclusionsRacial differences exist among DLBCL, FL, and CLL/SLL patients in the U.S. in terms of characteristics, incidence, and survival. The patterns vary across subtypes. More data collection and analysis are needed to more comprehensively describe and interpret the across-race and subtype differences.

Indexed as

AdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleHumansIncidenceInfantLeukemia, Lymphocytic, Chronic, B-CellLymphoma, FollicularLymphoma, Large B-Cell, DiffuseMaleMiddle AgedMultivariate AnalysisNon-Hodgkin lymphomaRacial differencesSEERSubtype

Identifiers

PMID25560974
PMCPMC4323749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.