Evidence map›Paper›PMID 25560878›Full record

ArticlePlant physiology2015

TYPE-ONE PROTEIN PHOSPHATASE4 regulates pavement cell interdigitation by modulating PIN-FORMED1 polarity and trafficking in Arabidopsis.

Xiaola Guo, Qianqian Qin, Jia Yan, Yali Niu, Bingyao Huang, Liping Guan, Yuan Li, Dongtao Ren, Jia Li, Suiwen Hou

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
7.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Type One Protein Phosphatase 4aD Negatively Regulates Cotton (International journal of molecular sciences · 2025
    Article
  6. Science advances · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Auxin Transporters-A Biochemical View.Cold Spring Harbor perspectives in biology · 2022
    Review
  11. Review
  12. Article
  13. Review
  14. Genome-wide characterization of soybeanFrontiers in plant science · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiaola GuoMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China (X.G., Q.Q., J.Y., Y.N., B.H., L.G., J.L., S.H.); andState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China (Y.L., D.R.).
Qianqian QinMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China (X.G., Q.Q., J.Y., Y.N., B.H., L.G., J.L., S.H.); andState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China (Y.L., D.R.).
Jia YanMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China (X.G., Q.Q., J.Y., Y.N., B.H., L.G., J.L., S.H.); andState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China (Y.L., D.R.).
Yali NiuMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China (X.G., Q.Q., J.Y., Y.N., B.H., L.G., J.L., S.H.); andState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China (Y.L., D.R.).
Bingyao HuangMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China (X.G., Q.Q., J.Y., Y.N., B.H., L.G., J.L., S.H.); andState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China (Y.L., D.R.).
Liping GuanMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China (X.G., Q.Q., J.Y., Y.N., B.H., L.G., J.L., S.H.); andState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China (Y.L., D.R.).
Yuan LiMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China (X.G., Q.Q., J.Y., Y.N., B.H., L.G., J.L., S.H.); andState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China (Y.L., D.R.).
Dongtao RenMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China (X.G., Q.Q., J.Y., Y.N., B.H., L.G., J.L., S.H.); andState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China (Y.L., D.R.).
Jia LiMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China (X.G., Q.Q., J.Y., Y.N., B.H., L.G., J.L., S.H.); andState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China (Y.L., D.R.).
Suiwen HouMinistry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China (X.G., Q.Q., J.Y., Y.N., B.H., L.G., J.L., S.H.); andState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China (Y.L., D.R.) housw@lzu.edu.cn.
Lanzhou University · CNChina Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In plants, cell morphogenesis is dependent on intercellular auxin accumulation. The polar subcellular localization of the PIN-FORMED (PIN) protein is crucial for this process. Previous studies have shown that the protein kinase PINOID (PID) and protein phosphatase6-type phosphatase holoenzyme regulate the phosphorylation status of PIN1 in root tips and shoot apices. Here, we show that a type-one protein phosphatase, TOPP4, is essential for the formation of interdigitated pavement cell (PC) pattern in Arabidopsis (Arabidopsis thaliana) leaf. The dominant-negative mutant topp4-1 showed severely inhibited interdigitated PC growth. Expression of topp4-1 gene in wild-type plants recapitulated the PC defects in the mutant. Genetic analyses suggested that TOPP4 and PIN1 likely function in the same pathway to regulate PC morphogenesis. Furthermore, colocalization, in vitro and in vivo protein interaction studies, and dephosphorylation assays revealed that TOPP4 mediated PIN1 polar localization and endocytic trafficking in PCs by acting antagonistically with PID to modulate the phosphorylation status of PIN1. In addition, TOPP4 affects the cytoskeleton pattern through the Rho of Plant GTPase-dependent auxin-signaling pathway. Therefore, we conclude that TOPP4-regulated PIN1 polar targeting through direct dephosphorylation is crucial for PC morphogenesis in the Arabidopsis leaf.

Indexed as

Cell PolarityActinsArabidopsisArabidopsis ProteinsBiological TransportCell ShapeCytoskeletonEndocytosisEpistasis, GeneticGenetic Complementation TestIndoleacetic AcidsMembrane Transport ProteinsMicrotubulesModels, BiologicalMorphogenesisMutationActinsArabidopsis ProteinsIndoleacetic AcidsMembrane Transport ProteinsPhosphoprotein PhosphatasesPIN1 protein, ArabidopsisProtein Phosphatase 1type-one protein phosphatase TOPP4, Arabidopsis

Identifiers

PMID25560878
PMCPMC4348754
OpenAlexW2023864284

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.