Evidence map›Paper›PMID 25560877›Full record

ArticlePlant physiology2015

Network of GRAS transcription factors involved in the control of arbuscule development in Lotus japonicus.

Li Xue, Haitao Cui, Benjamin Buer, Vinod Vijayakumar, Pierre-Marc Delaux, Stefanie Junkermann, Marcel Bucher

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
33.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 176 citations in OpenAlex.

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  12. Review
  13. Conservation of symbiotic signaling since the most recent common ancestor of land plants.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  14. Review
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  17. The receptor-like kinase ARK controls symbiotic balance across land plants.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Review
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Li XueBotanical Institute, Cologne Biocenter, Cluster of Excellence on Plant Sciences, University of Cologne, D-50674 Cologne, Germany (L.X., B.B.,V.V., S.J., M.B.);Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, D-50829 Cologne, Germany (H.C.); andDepartment of Agronomy, University of Wisconsin, Madison, Wisconsin 53706 (P.-M.D.).
Haitao CuiBotanical Institute, Cologne Biocenter, Cluster of Excellence on Plant Sciences, University of Cologne, D-50674 Cologne, Germany (L.X., B.B.,V.V., S.J., M.B.);Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, D-50829 Cologne, Germany (H.C.); andDepartment of Agronomy, University of Wisconsin, Madison, Wisconsin 53706 (P.-M.D.).
Benjamin BuerBotanical Institute, Cologne Biocenter, Cluster of Excellence on Plant Sciences, University of Cologne, D-50674 Cologne, Germany (L.X., B.B.,V.V., S.J., M.B.);Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, D-50829 Cologne, Germany (H.C.); andDepartment of Agronomy, University of Wisconsin, Madison, Wisconsin 53706 (P.-M.D.).
Vinod VijayakumarBotanical Institute, Cologne Biocenter, Cluster of Excellence on Plant Sciences, University of Cologne, D-50674 Cologne, Germany (L.X., B.B.,V.V., S.J., M.B.);Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, D-50829 Cologne, Germany (H.C.); andDepartment of Agronomy, University of Wisconsin, Madison, Wisconsin 53706 (P.-M.D.).
Pierre-Marc DelauxBotanical Institute, Cologne Biocenter, Cluster of Excellence on Plant Sciences, University of Cologne, D-50674 Cologne, Germany (L.X., B.B.,V.V., S.J., M.B.);Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, D-50829 Cologne, Germany (H.C.); andDepartment of Agronomy, University of Wisconsin, Madison, Wisconsin 53706 (P.-M.D.).
Stefanie JunkermannBotanical Institute, Cologne Biocenter, Cluster of Excellence on Plant Sciences, University of Cologne, D-50674 Cologne, Germany (L.X., B.B.,V.V., S.J., M.B.);Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, D-50829 Cologne, Germany (H.C.); andDepartment of Agronomy, University of Wisconsin, Madison, Wisconsin 53706 (P.-M.D.).
Marcel BucherBotanical Institute, Cologne Biocenter, Cluster of Excellence on Plant Sciences, University of Cologne, D-50674 Cologne, Germany (L.X., B.B.,V.V., S.J., M.B.);Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, D-50829 Cologne, Germany (H.C.); andDepartment of Agronomy, University of Wisconsin, Madison, Wisconsin 53706 (P.-M.D.) m.bucher@uni-koeln.de.
Cluster of Excellence on Plant Sciences · DEMax Planck Institute for Plant Breeding Research · DEUniversity of Cologne · DEUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arbuscular mycorrhizal (AM) fungi, in symbiosis with plants, facilitate acquisition of nutrients from the soil to their host. After penetration, intracellular hyphae form fine-branched structures in cortical cells termed arbuscules, representing the major site where bidirectional nutrient exchange takes place between the host plant and fungus. Transcriptional mechanisms underlying this cellular reprogramming are still poorly understood. GRAS proteins are an important family of transcriptional regulators in plants, named after the first three members: GIBBERELLIC ACID-INSENSITIVE, REPRESSOR of GAI, and SCARECROW. Here, we show that among 45 transcription factors up-regulated in mycorrhizal roots of the legume Lotus japonicus, expression of a unique GRAS protein particularly increases in arbuscule-containing cells under low phosphate conditions and displays a phylogenetic pattern characteristic of symbiotic genes. Allelic rad1 mutants display a strongly reduced number of arbuscules, which undergo accelerated degeneration. In further studies, two RAD1-interacting proteins were identified. One of them is the closest homolog of Medicago truncatula, REDUCED ARBUSCULAR MYCORRHIZATION1 (RAM1), which was reported to regulate a glycerol-3-phosphate acyl transferase that promotes cutin biosynthesis to enhance hyphopodia formation. As in M. truncatula, the L. japonicus ram1 mutant lines show compromised AM colonization and stunted arbuscules. Our findings provide, to our knowledge, new insight into the transcriptional program underlying the host's response to AM colonization and propose a function of GRAS transcription factors including RAD1 and RAM1 during arbuscule development.

Indexed as

Gene Regulatory NetworksGene Expression ProfilingGene Expression Regulation, PlantGenes, PlantGlucuronidaseLotusMutagenesis, InsertionalMutationMycorrhizaeOrgan SpecificityPhenotypePhylogenyPlant ProteinsProtein BindingSymbiosisTranscription FactorsGlucuronidasePlant ProteinsTranscription Factors

Identifiers

PMID25560877
PMCPMC4348782
OpenAlexW2099066779

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.