ReviewNature reviews. Gastroenterology & hepatology2015
Stress-related mucosal disease in the critically ill patient.
Review in Nature reviews. Gastroenterology & hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 7 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Incidence, timing, and risk factors for development of gastrointestinal bleeding in acute traumatic spinal cord injury: A systematic review.The journal of spinal cord medicine · 2026Pooled it
- Pharmacological interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units: a network meta-analysis.BMJ evidence-based medicine · 2025Pooled it
- Bibliometric and visualisation analyses of gastric ulcer knowledge areas and emerging trends, 2004-2024.Frontiers in medicine · 2025Pooled it
- The Prevalence of Gastrointestinal Bleeding in COVID-19 Patients: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2023Pooled it
- [S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare : Long version].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Guideline
- Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units.The Cochrane database of systematic reviews · 2018Pooled it
- Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.Intensive care medicine · 2017Guideline
- Effects of Plasma Albumin on the Pharmacokinetics of Esomeprazole in ICU Patients.BioMed research international · 2018Trial
- Gastrointestinal Bleeding in Severe Acute Pancreatitis: Pathogenesis and Clinical Management.Digestive diseases and sciences · 2026Review
- Efficacy and safety of ilaprazole for stress ulcer - associated upper gastrointestinal bleeding prophylaxis in critically ill patients: a randomized, double-blind, non-inferiority phase 3 trial.Annals of intensive care · 2026Article
- Association between Helicobacter pylori infection and hospital-acquired upper gastrointestinal bleeding: a prospective case-control study.BMC gastroenterology · 2025Article
- Predicting ICU Readmission in Patients With Cerebral Infarction: A Machine Learning Approach Using Neurophysiological and Clinical Data.Brain and behavior · 2025Article
- Knowledge, Attitudes, and Practices of Community Pharmacists Regarding Proton Pump Inhibitor (PPI) Use: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Gastrointestinal Bleeding Associated With Nasojejunal Tube Injury in a Patient With Septic Shock: A Case Report.Cureus · 2025Article
- Article
- Association between serum anion gap and all-cause mortality in critically ill patients with Gastrointestinal bleeding: insights from MIMIC-IV database.Scientific reports · 2025Article
- Management of Refractory Bleeding at the Duodenal Bulb Post-Trauma Using OTSC Combined With Interventional Embolization: A Case Report.Clinical case reports · 2025Article
- Vitamin E Inhibits Oxidative Stress and Inflammation in Stress-Induced Gastritis via Modulating Nrf2 and NF-κB Signalling Pathways.Journal of cellular and molecular medicine · 2025Article
- Peptic Ulcer Disease.The Korean journal of helicobacter and upper gastrointestinal research · 2025Review
- Yeokwisan: Standardised Herbal Formula Enhancing Gastric Mucosal Protection Against Gastric Ulcers in Mice, a Preclinical Study.Pharmaceuticals (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bleeding from stress-related mucosal disease in critically ill patients remains an important clinical management issue. Although only a small proportion (1-6%) of patients admitted to an intensive care unit (ICU) will bleed, a substantial proportion exhibit clinical risk factors (mechanical ventilation for >48 h and a coagulopathy) that predict an increased risk of bleeding. Furthermore, upper gastrointestinal mucosal lesions can be found in 75-100% of patients in ICUs. Although uncommon, stress-ulcer bleeding is a severe complication with an estimated mortality of 40-50%, mostly from decompensating an underlying condition or multiorgan failure. Although the vast majority of patients in ICUs receive stress-ulcer prophylaxis, largely with PPIs, some controversy surrounds their efficacy and safety. Indeed, no single trial has shown that stress-ulcer prophylaxis reduces mortality. Some reports suggest that the use of PPIs increases the risk of nosocomial infections. However, several meta-analyses and cost-effectiveness studies suggest PPIs to be more clinically effective and cost-effective than histamine-2 receptor antagonists, without considerable increases in nosocomial pneumonia. To help clinicians use the most appropriate strategy for treatment of patients in the ICU, this Review presents the latest information on all aspects of stress-related mucosal disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.