Evidence map›Paper›PMID 25560704›Full record

ReviewNature reviews. Endocrinology2015

Long non-coding RNAs as regulators of the endocrine system.

Marko Knoll, Harvey F Lodish, Lei Sun

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 1 synthesis or guideline pooled it, 246 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. miRNAs and T cell-mediated Immune Response in Disease.The Yale journal of biology and medicine · 2025
    Review
  5. Review
  6. OvineAnimals : an open access journal from MDPI · 2024
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Marko KnollWhitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142, USA.
Harvey F LodishWhitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142, USA.
Lei SunCardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, 8 College Road, 169857, Singapore.
Duke-NUS Medical School · SGMassachusetts Institute of Technology · US

Funding

MicroRNAs and hematopoietic differentiationR01DK068348 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LODISH, HARVEY F · 2004 to 2019
$8.3M
Lincs and miRs that regulate brown fat formation and functionR01DK047618 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LODISH, HARVEY F · 1994 to 2016
$6.3M
ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTIONR37DK047618 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LODISH, HARVEY F · 1998 to 2007
$4.8M
MicroRNAs and hematopoietic differentiationR56DK068348 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI BARTEL, DAVID P, LODISH, HARVEY F · 2010 to 2010
$230k
NIDDK NIH HHS DK047618‑25NIDDK NIH HHS DK068348-07NIDDK NIH HHS R01 DK047618NIDDK NIH HHS R01 DK068348NIDDK NIH HHS R37 DK047618NIDDK NIH HHS R56 DK068348
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are a large and diverse group of RNAs that are often lineage-specific and that regulate multiple biological functions. Many are nuclear and are essential parts of ribonucleoprotein complexes that modify chromatin segments and establish active or repressive chromatin states; others are cytosolic and regulate the stability of mRNA or act as microRNA sponges. This Review summarizes the current knowledge of lncRNAs as regulators of the endocrine system, with a focus on the identification and mode of action of several endocrine-important lncRNAs. We highlight lncRNAs that have a role in the development and function of pancreatic β cells, white and brown adipose tissue, and other endocrine organs, and discuss the involvement of these molecules in endocrine dysfunction (for example, diabetes mellitus). We also address the associations of lncRNAs with nuclear receptors involved in major hormonal signalling pathways, such as estrogen and androgen receptors, and the relevance of these associations in certain endocrine cancers.

Indexed as

Adipose TissueAnimalsCircadian RhythmDiabetes MellitusEndocrine Gland NeoplasmsEndocrine SystemEndocrine System DiseasesGlucoseHumansInsulin-Secreting CellsRNA, Long NoncodingSignal TransductionGlucoseRNA, Long Noncoding

Identifiers

PMID25560704
PMCPMC4376378
OpenAlexW2036001944

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.