Evidence map›Paper›PMID 25560695›Full record

ArticleBMB reports2015

Heat shock protein X purified from Mycobacterium tuberculosis enhances the efficacy of dendritic cells-based immunotherapy for the treatment of allergic asthma.

Hye-Young Kim, Hyun Kyu Kang, Joon Cho, In Duk Jung, Gun Young Yoon, Min-Goo Lee, Sung Jae Shin, Won Sun Park, Jong-Hwan Park, Seung-Wook Ryu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMB reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Inhalation of nebulizedAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Hye-Young KimDepartment of Pediatrics, Pusan National University School of Medicine, Medical Research Institute of Pusan National University Hospital, Pusan 602-739, Korea.
Hyun Kyu KangDepartment of Microbiology and Immunology, School of Medicine, Pusan National University, Pusan 602-739, Korea.
Joon ChoDepartment of Neurosurgery, Konkuk University Hospital, Seoul 380-701, Korea.
In Duk JungDepartment of Immunology, Lab of Dendritic Cell Differentiation & Regulation, KU open innovation center and School of Medicine, Konkuk University, Chungju 380-701, Korea.
Gun Young YoonDepartment of Immunology, Lab of Dendritic Cell Differentiation & Regulation, KU open innovation center and School of Medicine, Konkuk University, Chungju 380-701, Korea.
Min-Goo LeeDepartment of Physiology, College of Medicine, Korea University, Seoul 136-705, Korea.
Sung Jae ShinDepartment of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 120-752, Korea.
Won Sun ParkDepartment of Physiology, School of Medicine, Kangwon National University, Chuncheon 200-701, Korea.
Jong-Hwan ParkDepartment of Biochemistry, College of Medicine, Konyang University, Daejeon 302-711, Korea.
Seung-Wook RyuCell Signaling and Bioimaging Laboratory, Department of Bio and Brain Engineering, KAIST, Daejeon 305-701, Korea.
Yeong-Min ParkDepartment of Immunology, Lab of Dendritic Cell Differentiation & Regulation, KU open innovation center and School of Medicine, Konkuk University, Chungju 380-701, Korea.
Ji Chang YouNational Research Laboratory of Molecular Virology, Department of Pathology, School of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.
Catholic University of Korea · KRKangwon National University · KRKonyang University · KRKorea University · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells play an important role in determining whether naïve T cells mature into either Th1 or Th2 cells. We determined whether heat-shock protein X (HspX) purified from Mycobacterium tuberculosis regulates the Th1/Th2 immune response in an ovalbumin (OVA)-induced murine model of asthma. HspX increased interferon-gamma, IL-17A, -12 and transforming growth factor (TGF)-β production and T-bet gene expression but reduced IL-13 production and GATA-3 gene expression. HspX also inhibited asthmatic reactions as demonstrated by an increase in the number of eosinophils in bronchoalveolar lavage fluid, inflammatory cell infiltration in lung tissues, airway luminal narrowing, and airway hyper-responsiveness. Furthermore, HspX enhanced OVA-induced decrease of regulatory T cells in the mediastinal lymph nodes. This study provides evidence that HspX plays critical roles in the amelioration of asthmatic inflammation in mice. These findings provide new insights into the immunotherapeutic role of HspX with respect to its effects on a murine model of asthma.

Indexed as

ImmunotherapyAdoptive TransferAnimalsAsthmaDendritic CellsGATA3 Transcription FactorHeat-Shock ProteinsHypersensitivityInflammation MediatorsLungMiceMycobacterium tuberculosisOvalbuminGata3 protein, mouseGATA3 Transcription FactorHeat-Shock ProteinsInflammation MediatorsOvalbumin

Identifiers

PMID25560695
PMCPMC4453021
OpenAlexW1964572631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.