ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
p21-Activated kinase 5 affects cisplatin-induced apoptosis and proliferation in hepatocellular carcinoma cells.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Hyperactivation of p21-Activated Kinases in Human Cancer and Therapeutic Sensitivity.Biomedicines · 2023Review
- P-21 Activated Kinases in Liver Disorders.Cancers · 2023Review
- Review
- RHO GTPase family in hepatocellular carcinoma.Experimental hematology & oncology · 2022Review
- MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular carcinoma by targeting PAK5 mediated β-catenin/ABCB1 signaling pathway.Journal of biomedical science · 2021Article
- P21-activated kinase 5 potentiates the chemoresistant phenotype of liver cancer.Signal transduction and targeted therapy · 2021Article
- p21-Activated Kinases in Thyroid Cancer.Endocrinology · 2020Review
- PAK5 facilitates the proliferation, invasion and migration in colorectal cancer cells.Cancer medicine · 2020Article
- Activation of Mitochondrial 2-Oxoglutarate Dehydrogenase by Cocarboxylase in Human Lung Adenocarcinoma Cells A549 Is p53/p21-Dependent and Impairs Cellular Redox State, Mimicking the Cisplatin Action.International journal of molecular sciences · 2020Article
- PAK5 promotes the migration and invasion of cervical cancer cells by phosphorylating SATB1.Cell death and differentiation · 2019Article
- Exogenous OGF enhances the anti-tumor activity of cisplatin on hepatocellular carcinoma.International journal of clinical and experimental pathology · 2019Article
- MiR-106a-5p inhibits the cell migration and invasion of renal cell carcinoma through targeting PAK5.Cell death & disease · 2017Article
- Review
- Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer.World journal of gastroenterology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p21-Activated kinase 5 (PAK5) is the last identified member of the PAK family. The PAKs are highly conserved serine/threonine and effector proteins for Cdc42 and Rac and are essential in regulating cell motility and survival. Previous studies have demonstrated that PAK5 played a pivotal role in apoptosis, proliferation, cancer migration, and invasion. However, the biological function of PAK5 in hepatocellular carcinoma, as well as its underlying mechanism, still remains to be fully elucidated. In the present study, we demonstrated that PAK5 markedly inhibited cisplatin-induced apoptosis and promoted cell proliferation in hepatocellular carcinoma cells. Moreover, our results showed that overexpression of PAK5 contributed to cell cycle regulation. In order to elucidate the underlying mechanism of PAK5 on cisplatin-induced apoptosis and cell cycle regulation, we also examined the protein expressions of chk2 and p-chk2. In summary, our study investigated the role of PAK5 in cisplatin-induced cellular processes and provided evidence of its underlying mechanism.
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