ArticleEuropean journal of clinical pharmacology2015
Prescription and indication trends of antidepressant drugs in the Netherlands between 1996 and 2012: a dynamic population-based study.
Article in European journal of clinical pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Use of Antidepressive Agents and Bone Mineral Density in Women: A Meta-Analysis.International journal of environmental research and public health · 2018Pooled it
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- Sexual Dysfunction in Male Patients After Initiating Treatment with Antidepressants.Drug safety · 2026Article
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- Ten-year analgesic utilization patterns and economic implications in Portugal.British journal of clinical pharmacology · 2025Article
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- Reasons for Discontinuation or Change of Selective Serotonin Reuptake Inhibitors in Online Drug Reviews.JAMA network open · 2023Article
- Trends in the registration of anxiety in Belgian primary care from 2000 to 2021: a registry-based study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
- Impact of Sertraline, Fluoxetine, and Escitalopram on Psychological Distress among United States Adult Outpatients with a Major Depressive Disorder.Healthcare (Basel, Switzerland) · 2023Article
- Analysis and identification of drug similarity through drug side effects and indications data.BMC medical informatics and decision making · 2023Article
- Antidepressant sertraline increases thioflavin-S and Congo red deposition in APPswe/PSEN1dE9 transgenic mice.Frontiers in pharmacology · 2023Article
- Maternal Depression and Antidepressant Use During Pregnancy and Associations with Depressive Symptoms and Suicidality in Adolescent Children.Clinical epidemiology · 2023Article
- Why psychiatry needs an honest dose of gentle medicine.Frontiers in psychiatry · 2023Review
- Synergistic Effects of the Combinational Use of Escitalopram Oxalate and 5-Fluorouracil on the Inhibition of Gastric Cancer SNU-1 Cells.International journal of molecular sciences · 2022Article
- Treatment indications and potential off-label use of antidepressants among older adults: A population-based descriptive study in Denmark.International journal of geriatric psychiatry · 2022Article
- Withdrawal Syndrome Following Discontinuation of 28 Antidepressants: Pharmacovigilance Analysis of 31,688 Reports from the WHO Spontaneous Reporting Database.Drug safety · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAntidepressant drug use increases worldwide. It is pivotal to closely monitor the use of antidepressants and to determine in what subpopulations the rise is most substantial. In a Dutch primary care database, we aimed to investigate the (sex- and age-specific) prevalence and incidence of antidepressant prescription and to monitor the indication of incident prescriptions over a 17-year period (1996-2012).
methodsThis study, embedded in the Integrated Primary Care Information database, included all patients aged 10 years or older. Per calendar year, prevalence and incidence of antidepressant drug prescription were calculated by drug class (tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and others), sex, and age. The indication of incident prescriptions (e.g., depression, anxiety, sleep disorders, and neuropathic pain) was determined based on the International Classification of Primary Care codes.
resultsIn total, 1.49 million patients were included. For all antidepressants together, the prevalence increased over time. However, incident prescription of specific SSRIs decreased from 2000 onward. During the study period, incidence and prevalence were higher in older and female patients. The increase in prevalence and the decrease in incidence were more pronounced in females than that in males. Furthermore, antidepressants were increasingly prescribed for indications such as neuropathic pain and sleep disorders.
conclusionsIn Dutch primary care, prevalent prescription of antidepressants continued to increase, but incident prescription of particular SSRIs decreased from 2000 onward. In later years, antidepressants were less frequently prescribed for depression-related indications in incident users.
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