ReviewJournal of Zhejiang University. Science. B2015
Epigenetic and metabolic regulation of breast cancer stem cells.
Review in Journal of Zhejiang University. Science. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- DNA methylation-regulated AKAP12 expression modulates ECM remodeling and ADP/FAD ratio to influence prognosis in ovarian cancer.Journal of ovarian research · 2026Article
- Bromodomain (BrD) Family Members as Regulators of Cancer Stemness-A Comprehensive Review.International journal of molecular sciences · 2023Review
- A Positive Feedback Loop Between c-Myc Upregulation, Glycolytic Shift, and Histone Acetylation Enhances Cancer Stem Cell-like Property and Tumorigenicity of Cr(VI)-transformed Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- TGF-β induced EMT and stemness characteristics are associated with epigenetic regulation in lung cancer.Scientific reports · 2020Article
- Nuclear translocation of PLSCR1 activates STAT1 signaling in basal-like breast cancer.Theranostics · 2020Article
- Quantification of the Underlying Mechanisms and Relationships Among Cancer, Metastasis, and Differentiation and Development.Frontiers in genetics · 2019Article
- ME1 promotes basal-like breast cancer progression and associates with poor prognosis.Scientific reports · 2018Article
- Article
- EBV Associated Breast Cancer Whole Methylome Analysis Reveals Viral and Developmental Enriched Pathways.Frontiers in oncology · 2018Article
- The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells.PloS one · 2018Article
- DNA methylation in the tumor microenvironment.Journal of Zhejiang University. Science. B · 2017Review
- AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program.The Journal of experimental medicine · 2017Article
- Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer.Oncotarget · 2017Article
- Exosomes-mediate microRNAs transfer in breast cancer chemoresistance regulation.American journal of cancer research · 2016Review
- Breast metastasis of gastric signet-ring cell carcinoma.Journal of Zhejiang University. Science. BArticle
- Green tea polyphenols induce cell death in breast cancer MCF-7 cells through induction of cell cycle arrest and mitochondrial-mediated apoptosis.Journal of Zhejiang University. Science. BArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer has a relatively high mortality rate in women due to recurrence and metastasis. Increasing evidence has identified a rare population of cells with stem cell-like properties in breast cancer. These cells, termed cancer stem cells (CSCs), which have the capacity for self-renewal and differentiation, contribute significantly to tumor progression, recurrence, drug resistance and metastasis. Clarifying the mechanisms regulating breast CSCs has important implications for our understanding of breast cancer progression and therapeutics. A strong connection has been found between breast CSCs and epithelial mesenchymal transition (EMT). In addition, recent studies suggest that the maintenance of the breast CSC phenotype is associated with epigenetic and metabolic regulation. In this review, we focus on recent discoveries about the connection between EMT and CSC, and advances made in understanding the roles and mechanisms of epigenetic and metabolic reprogramming in controlling breast CSC properties.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.