ArticlePloS one2015
Insulin resistance is associated with intraocular pressure elevation in a non-obese Korean population.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
- Impact of Insulin Resistance on Retinal Ganglion Cell Layer Structures: Findings from the Korea National Health and Nutrition Examination Survey.Journal of clinical medicine · 2026Article
- Relationship between body adiposity, metabolic status, and intraocular pressure in dogs.Journal of veterinary internal medicine · 2026Article
- Association Between Intraocular Pressure and Risk Factors for Metabolic Syndrome in Korea.Journal of Korean medical science · 2025Article
- Association between metabolic syndrome and the risk of glaucoma: a meta-analysis of observational studies.Diabetology & metabolic syndrome · 2024Article
- Insulin resistance in the retina: possible implications for certain ocular diseases.Frontiers in endocrinology · 2024Review
- Metabolic Health, Obesity, and Intraocular Pressure.Journal of clinical medicine · 2023Article
- Article
- Association between diabetes status and subsequent onset of glaucoma in postmenopausal women.Scientific reports · 2021Article
- Citicoline Modulates Glaucomatous Neurodegeneration Through Intraocular Pressure-Independent Control.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Polygenetic-Risk Scores for A Glaucoma Risk Interact with Blood Pressure, Glucose Control, and Carbohydrate Intake.Nutrients · 2020Article
- Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.American journal of ophthalmology · 2019Article
- Cholinergic nervous system and glaucoma: From basic science to clinical applications.Progress in retinal and eye research · 2019Review
- Article
- An Overview of Ophthalmologic Survey Methodology in the 2008-2015 Korean National Health and Nutrition Examination Surveys.Korean journal of ophthalmology : KJO · 2015Review
- Insulin Resistance Is a Risk Factor for Increased Intraocular Pressure: The Hisayama Study.Investigative ophthalmology & visual science · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on reports of an association between elevated intraocular pressure (IOP) and metabolic syndrome (MetS), and the major role of insulin resistance (IR) in MetS pathogenesis, a positive association between IOP and IR has been hypothesized. Although Asian populations tend to have lower body mass indices (BMIs) than Western populations, they tend to have a higher risk of developing MetS. This study examined the hypothesis that the association between IOP and IR differs by obesity status in an Asian population, by examining a nationally representative sample of South Korean adults. Data collected from 4,621 South Korean adults regarding demographic, lifestyle, and laboratory parameters by the 2010 Korea National Health and Nutrition Examination Survey were subjected to linear regression analysis to evaluate the relationship between IOP and metabolic profiles. After adjusting for confounding factors, the data were subjected to multiple linear regression analysis to examine the association between IR, as measured by the homeostasis model assessment of insulin resistance (HOMA-IR), and IOP. Obesity was defined as BMI≥27.5 kg/m2, and the subjects were divided into obese vs. non-obese groups for investigation of the association between IR and IOP according to obesity status. IOP was found to correlate with fasting blood sugar, total cholesterol, insulin, and HOMA-IR values in non-obese men; and with BMI, waist circumference, triglycerides, total cholesterol, HOMA-IR, and low-density lipoprotein cholesterol values in non-obese women, whereas no association between IOP and IR was found in obese men or women. IOP was significantly associated with IR in non-obese men and women after adjusting for age, and in non-obese men after adjusting for age, BMI, and lifestyle and demographic factors. These findings indicate that a positive and independent relationship exists between IOP and IR in non-obese individuals only, suggesting that other factors likely contribute to IOP elevation in obese individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.