ArticleBMC bioinformatics2014
A new statistical approach to combining p-values using gamma distribution and its application to genome-wide association study.
Article in BMC bioinformatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluation of Cell-Specific Alterations in Alzheimer's Disease and Relevance of In Vitro Models.Genes · 2023Pooled it
- Evaluating the Cauchy combination test for count data.PloS one · 2025Article
- Label-free multimodal electro-thermo-mechanical (ETM) phenotyping as a novel biomarker to differentiate between normal, benign, and cancerous breast biopsy tissues.Journal of biological engineering · 2023Article
- Mussel mass mortality in the Clinch River, USA: metabolomics detects affected pathways and biomarkers of stress.Conservation physiology · 2023Article
- An integrated cluster-wise significance measure for fMRI analysis.Human brain mapping · 2022Article
- Robust tests for combining p-values under arbitrary dependency structures.Scientific reports · 2022Article
- Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences.PLoS genetics · 2021Article
- A parametric meta-analysis.Statistics in medicine · 2019Article
- Combining CDKN1A gene expression and genome-wide SNPs in a twin cohort to gain insight into the heritability of individual radiosensitivity.Functional & integrative genomics · 2019Article
- Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians.PLoS genetics · 2019Article
- Gene-level differential analysis at transcript-level resolution.Genome biology · 2018Article
- Statistical power and utility of meta-analysis methods for cross-phenotype genome-wide association studies.PloS one · 2018Article
- Article
- A gene-based test of association through an orthogonal decomposition of genotype scores.Human genetics · 2017Article
- Advances in translational bioinformatics facilitate revealing the landscape of complex disease mechanisms.BMC bioinformatics · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundCombining information from different studies is an important and useful practice in bioinformatics, including genome-wide association study, rare variant data analysis and other set-based analyses. Many statistical methods have been proposed to combine p-values from independent studies. However, it is known that there is no uniformly most powerful test under all conditions; therefore, finding a powerful test in specific situation is important and desirable.
resultsIn this paper, we propose a new statistical approach to combining p-values based on gamma distribution, which uses the inverse of the p-value as the shape parameter in the gamma distribution.
conclusionsSimulation study and real data application demonstrate that the proposed method has good performance under some situations.
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Registered trials
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