Evidence map›Paper›PMID 25559333›Full record

ArticleNeurobiology of aging2015

Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia.

Ruth M Barrientos, Vanessa M Thompson, Meagan M Kitt, Jose Amat, Matthew W Hale, Matthew G Frank, Nicole Y Crysdale, Christopher E Stamper, Patrick A Hennessey, Linda R Watkins and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
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  4. Review
  5. Supplementation with Vitamin DInternational journal of molecular sciences · 2023
    Article
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  8. Article
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  11. Review
  12. Adolescent stress sensitizes the adult neuroimmune transcriptome and leads to sex-specific microglial and behavioral phenotypes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Ruth M BarrientosDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA. Electronic address: ruth.barrientos@colorado.edu.
Vanessa M ThompsonDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Meagan M KittDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Jose AmatDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Matthew W HaleDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA; School of Psychological Science, La Trobe University, Melbourne Campus, Victoria, Australia.
Matthew G FrankDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Nicole Y CrysdaleDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Christopher E StamperDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Patrick A HennesseyDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Linda R WatkinsDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Robert L SpencerDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Christopher A LowryDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Steven F MaierDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
University of Colorado Boulder · US

Funding

Neuroinflammation, Inflammatory Challenge, and MemoryR01AG028271 · NIA · UNIVERSITY OF COLORADO · PI MAIER, STEVEN F · 2006 to 2016
$3.8M
Preventing Transition of Acute-to-Chronic Neuropathic Pain: Models, Mechanisms &R01DE021966 · NIDCR · UNIVERSITY OF COLORADO · PI BARTH, DANIEL S., FLESHNER, MONIKA · 2011 to 2015
$2.0M
NIA NIH HHS R01 AG028271NIA NIH HHS R01AG028271NIDCR NIH HHS R01 DE021966
6 · The paper itself

Abstract

Healthy aging individuals are more likely to suffer profound memory impairments following an immune challenge than are younger adults. These challenges produce a brain inflammatory response that is exaggerated with age. Sensitized microglia found in the normal aging brain are responsible for this amplified response, which in turn interferes with processes involved in memory formation. Here, we examine factors that may lead aging to sensitize microglia. Aged rats exhibited higher corticosterone levels in the hippocampus, but not in plasma, throughout the daytime (diurnal inactive phase). These elevated hippocampal corticosterone levels were associated with increased hippocampal 11β-hydroxysteroid dehydrogenase type 1 protein expression, the enzyme that catalyzes glucocorticoid formation and greater hippocampal glucocorticoid receptor (GR) activation. Intracisternal administration of mifepristone, a GR antagonist, effectively reduced immune-activated proinflammatory responses, specifically from hippocampal microglia and prevented Escherichia coli-induced memory impairments in aged rats. Voluntary exercise as a therapeutic intervention significantly reduced total hippocampal GR expression. These data strongly suggest that increased GR activation in the aged hippocampus plays a critical role in sensitizing microglia.

Indexed as

11-beta-Hydroxysteroid Dehydrogenase Type 1AgingAnimalsCatalysisCells, CulturedCorticosteroneHippocampusInflammationMaleMemoryMemory DisordersMicrogliaMifepristonePhysical Conditioning, AnimalRats, Inbred F344Receptors, Glucocorticoid11-beta-Hydroxysteroid Dehydrogenase Type 1CorticosteroneMifepristoneReceptors, GlucocorticoidAutomated blood samplingGR activationIn vivo microdialysisMemory impairmentsMicroglial immunophenotypeMicroglial sensitizationMifepristoneNormal agingVoluntary exercise

Identifiers

PMID25559333
PMCPMC4346455
OpenAlexW2166436861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.