Evidence map›Paper›PMID 25559296›Full record

ArticleActa psychiatrica Scandinavica2015

Current smoking is associated with worse cognitive and adaptive functioning in serious mental illness.

C A Depp, C R Bowie, B T Mausbach, P Wolyniec, M H Thornquist, J R Luke, J A McGrath, A E Pulver, T L Patterson, P D Harvey

Abstract read
In one paragraph

Article in Acta psychiatrica Scandinavica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Epigenetic GrimAge acceleration and cognitive impairment in bipolar disorder.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2022
    Article
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  14. Impact of smoking Behavior on cognitive functioning in persons at risk for psychosis and healthy controls: A longitudinal study.European psychiatry : the journal of the Association of European Psychiatrists · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

C A DeppDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, San Diego, CA, USA.
C R Bowie
B T Mausbach
P Wolyniec
M H Thornquist
J R Luke
J A McGrath
A E Pulver
T L Patterson
P D Harvey

Funding

Chronic Psychiatric Disorders: Linking Genes to Functional DisabilityR01MH079784 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PULVER, ANN E · 2007 to 2011
$3.8M
Real-Time Mobile Cognitive Behavioral Intervention for Serious Mental IllnessR01MH100417 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2013 to 2016
$2.1M
Validating Assessments of Real-World OutcomeR01MH078737 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATTERSON, THOMAS L. · 2007 to 2011
$1.7M
Validation of Measures of real-world outcomeR01MH078775 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARVEY, PHILIP D. · 2007 to 2011
$1.7M
NIMH NIH HHS R01 MH078737NIMH NIH HHS R01MH078737NIMH NIH HHS R01 MH078775NIMH NIH HHS R01 MH079784NIMH NIH HHS R01MH079784NIMH NIH HHS R01 MH100417NIMH NIH HHS R01MH100417NIMH NIH HHS R01MH78775
6 · The paper itself

Abstract

objectiveCigarette smoking is highly prevalent among people with bipolar disorder or schizophrenia. Few studies have examined whether smoking history is associated with adaptive functioning among individuals diagnosed with these serious mental illnesses.

methodIn a large relatively homogenous cohort of patients with either bipolar disorder (n=363) or schizophrenia (n=400), we investigated the association between cigarette smoking status, intensity, and cumulative exposure and performance on a comprehensive battery of neurocognitive, functional capacity, and informant-rated functional measures. The associations were adjusted for variation in sociodemographic indicators, psychopathologic symptoms, and substance use.

resultsThere was an average of 12 pack years of smoking across the sample. People with schizophrenia reported double the rate of current smoking compared to patients with bipolar disorder. Adjusting for demographic covariates, current smokers had worse composite cognitive functioning and poorer functional outcome than past or never smokers. There were no significant differences between never and past smokers, and these effects were evident in both bipolar disorder and schizophrenia.

conclusionCurrent smokers with either schizophrenia or bipolar disorder evidence worse cognitive and adaptive functioning functional outcome, even when demographic covariates are considered.

Indexed as

Adaptation, PsychologicalBipolar DisorderCognitionExecutive FunctionSchizophreniaSchizophrenic PsychologyTobacco Use DisorderAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesSelf ReportSmokingBipolar DisorderCognitionNeuropsychologyNicotinePsychosisSchizophrenia

Identifiers

PMID25559296
PMCPMC4400207

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.